II. Pathophysiology

  1. Streptococcus Viridans are a heterogeneous group
    1. Alpha-hemolytic Streptococcus (Gram Positive Cocci)
    2. Viridans is named for the greenish glow on Blood Culture media (alpha-hemolytic effects on RBCs)
    3. Subdivided into at least 4 sub groups (see below)
  2. Normal human colonization
    1. Gastrointestinal Tract
    2. Oropharynx
  3. Human Infections
    1. Subacute Bacterial Endocarditis
      1. Extracellular Dextran allows binding to Heart Valves (Streptococcus Viridans, Group D Strep, Enterococcus)
    2. Dental Infections (esp. Streptococcus Mutans)
      1. S. mutans binds teeth and ferments sugars to acids, leading to dental decay
    3. Abscesses
      1. Streptococcus Anginosus Group (intermedius) are normal, microaerophilic flora in the Gastrointestinal Tract
      2. Brain and Liver Abscesses
        1. Streptococcus Anginosus Group either alone or in mixed Bacterial Infections with Bacteroides
        2. Patients may present with Occult Bacteremia

III. Types

  1. Streptococcus Mutans Group
    1. Streptococcus Mutans
    2. Streptococcus sobrinus
    3. Streptococcus criceti
    4. Streptococcus rattus
    5. Streptococcus downei
    6. Streptococcus macacae
  2. Streptococcus Mitis Group
    1. Streptococcus Mitis
    2. Streptococcus sanguis
    3. Streptococcus parasanguis
    4. Streptococcus gordonii
    5. Streptococcus crista
    6. Streptococcus infantis
    7. Streptococcus oralis
    8. Streptococcus peroris
  3. Streptococcus Salivarius Group
    1. Streptococcus Salivarius
    2. Streptococcus vestibularis
    3. Streptococcus thermophilus
  4. Streptococcus Anginosus Group (Streptococcus Milleri Group, Intermedius group)
    1. Streptococcus Anginosus
    2. StreptococcusConstellatus
    3. Streptococcus Intermedius

IV. References

  1. Gladwin, Trattler and Mahan (2014) Clinical Microbiology, Medmaster, Fl, p. 31-2
  2. Doern (2010) J Clin Microbiol 48(11):3829-35 +PMID: 20810781 [PubMed]

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Related Studies

Ontology: Streptococcus mutans (C0038409)

Definition (CSP) polysaccharide producing species of Streptococcus isolated from human dental plaque.
Definition (MSH) A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
Concepts Bacterium (T007)
MSH D013295
SnomedCT 214001
English Streptococcus mutans, STREP MUTANS, mutan streptococcus, streptococcus mutans, mutans streptococcus, Streptococcus mutans Clarke 1924, STREPTOCOCCUS MUTANS, Streptococcus mutans aggregate, Streptococcus mutans (organism)
Swedish Streptococcus mutans
Czech Streptococcus mutans
Finnish Streptococcus mutans
Croatian STREPTOCOCCUS MUTANS
Polish Streptococcus mutans
Norwegian Streptococcus mutans
Spanish Streptococcus mutans (organismo), Streptococcus mutans
French Streptococcus mutans
German Streptococcus mutans
Italian Streptococcus mutans
Russian STREPTOCOCCUS MUTANS
Dutch Streptococcus mutans
Portuguese Streptococcus mutans

Ontology: Streptococcus mitis (C0318146)

Definition (NCI) A mesophilic, alpha-hemolytic species of Streptococcus that is a normal constituent of human mouth flora but that can cause endocarditis.
Definition (CSP) species of gram-positive, coccoid bacteria commensal in the respiratory tract.
Definition (MSH) A species of gram-positive, coccoid bacteria commensal in the respiratory tract.
Concepts Bacterium (T007)
MSH D034361
SnomedCT 61607002, 57997003
English Streptococcus mitis, mitis streptococcus, streptococcus mitis, Streptococcus mitis Andrewes and Horder 1906 emend. Judicial Commission 1993, Streptococcus mitis Andrewes and Horder 1906 (Approved Lists 1980) emend. Kilian et al. 1989, Streptococcus mitior (organism), STREPTOCOCCUS MITIS, Streptococcus mitior, Streptococcus mitis (organism)
Swedish Streptococcus mitis
Czech Streptococcus mitis
Finnish Streptococcus mitis
Polish Streptococcus mitis
Spanish Streptococcus mitior, Streptococcus mitior (concepto no activo), Streptococcus mitis (organismo), Streptococcus mitis
Norwegian Streptococcus mitis
French Streptococcus mitis
German Streptococcus mitis
Italian Streptococcus mitis
Russian STREPTOCOCCUS MITIS
Dutch Streptococcus mitis
Portuguese Streptococcus mitis

Ontology: Streptococcus anginosus (C0318147)

Definition (NCI) A species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for arginine deamination, esculin hydrolysis and beta glucosidase and negative for urease, catalase, sialidase and hyaluronidase. It can ferment amygdalin, lactose, salicin, cellobiose, trehalose and raffinose but not arabinose, glycerol, inulin, sorbitol, mannitol or ribose. S. anginosis is found in normal human urogenital and gastrointestinal tracts and is involved in opportunistic infections of abscesses.
Definition (NCI_CDISC) Any bacterial organism that can be assigned to the species Streptococcus anginosis.
Definition (MSH) A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is the most frequently seen isolate of that group, has a proclivity for abscess formation, and is most often isolated from the blood, gastrointestinal, and urogenital tract.
Concepts Bacterium (T007)
MSH D034366
SnomedCT 44304009
LNC LP145778-9
Swedish Streptococcus anginosus
Czech Streptococcus anginosus
English Streptococcus anginosus, Streptococcus anginosus (Andrewes and Horder 1906) Smith and Sherman 1938 (Approved Lists 1980) emend. Whiley and Beighton 1991, Streptococcus anginosis, Streptococcus anginosus (Andrewes and Horder 1906) Smith and Sherman 1938 (Approved Lists 1980) emend. Coykendall et al. 1987, STREPTOCOCCUS ANGINOSIS, Streptococcus anginosus (organism)
Finnish Streptococcus anginosus
Polish Streptococcus anginosus
Norwegian Streptococcus anginosus
Spanish Streptococcus anginosus (organismo), Streptococcus anginosus
French Streptococcus anginosus
German Streptococcus anginosus
Italian Streptococcus anginosus
Russian STREPTOCOCCUS ANGINOSUS
Dutch Streptococcus anginosus
Portuguese Streptococcus anginosus

Ontology: Streptococcus intermedius (C0318151)

Definition (NCI_CDISC) Any bacterial organism that can be assigned to the species Streptococcus intermedius.
Definition (NCI) A species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for arginine deaminase, esculin hydrolysis, hyaluronidase, sialidase, beta galactosidase and beta glucosidase and negative for urease and catalase. It can ferment lactose and trehalose but not arabinose, glycerol, inulin, sorbitol, raffinose or mannitol. S. intermedius is a commensal organism in humans that can be an opportunistic pathogen causing brain and liver abscesses, periodontitis and purulent infections.
Definition (MSH) A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is commonly found in the oropharynx flora and has a proclivity for abscess formation, most characteristically in the CENTRAL NERVOUS SYSTEM and LIVER.
Concepts Bacterium (T007)
MSH D034367
SnomedCT 62170002
LNC LP145781-3
English Streptococcus intermedius, Streptococcus intermedius Prevot 1925 (Approved Lists 1980) emend. Whiley and Beighton 1991, streptococcus intermedius, STREPTOCOCCUS INTERMEDIUS, Streptococcus intermedius (organism), Streptococcus MG intermedius, Streptococcus MG
Swedish Streptococcus intermedius
Czech Streptococcus intermedius
Spanish Streptococcus MG intermedius, Streptococcus intermedius (organismo), Streptococcus intermedius
Finnish Streptococcus intermedius
Polish Streptococcus intermedius
Norwegian Streptococcus intermedius
French Streptococcus intermedius
German Streptococcus intermedius
Italian Streptococcus intermedius
Russian STREPTOCOCCUS INTERMEDIUS
Dutch Streptococcus intermedius
Portuguese Streptococcus intermedius

Ontology: Streptococcus Viridans Group (C0318157)

Definition (NCI_CDISC) A non-taxonomic grouping of species within the Streptococcus genus that are alpha-hemolytic and do not express Lancefield antigens.
Definition (NCI) A group of Streptococcal species that produce green-colored colonies on blood agar plates.
Definition (NCI) A non taxonomic grouping of species within the Streptococcus genus that are alpha hemolytic and do not express Lancefield antigens.
Definition (MSH) A large heterogeneous group of mostly alpha-hemolytic streptococci. They colonize the respiratory tract at birth and generally have a low degree of pathogenicity. This group of species includes STREPTOCOCCUS MITIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS SANGUIS; STREPTOCOCCUS SOBRINUS; and the STREPTOCOCCUS MILLERI GROUP. The latter are often beta-hemolytic and commonly produce invasive pyogenic infections including brain and abdominal abscesses.
Concepts Bacterium (T007)
MSH D034363
SnomedCT 31703004
French Groupe des streptocoques viridans, Streptocoques du groupe viridans, Streptocoques viridans
Swedish Viridans streptococci
Czech viridující streptokoky, Streptococcus - skupina viridans
English Streptococcus viridans group, Viridans streptococcus, Streptococcus viridans Group, streptococcus viridans, viridans streptococci, streptococcus viridans group, streptococci viridans, viridans streptococcus, STREPTOCOCCUS VIRIDANS GROUP, Streptococcus Viridans Group, Viridans Streptococci, STREPTOCOCCUS VIRIDANS, VIRIDANS STREPTOCOCCUS, Streptococcus viridans, Streptococcus, viridans group, Viridans group streptococci, Streptococcus, viridans group (organism)
Finnish Viridans-streptokokit
Japanese ヴィリダンス型連鎖球菌
Spanish Estreptococos Viridans, Estreptococos del Grupo Viridans, Streptococcus Grupo Viridans, Streptococci Viridans, Streptococcus, grupo viridans (organismo), Streptococcus, grupo viridans, Streptococcus del Grupo Viridans
Italian Streptococci gruppo Viridans, Viridans Streptococci
Portuguese Estreptococos Viridans, Estreptococos do Grupo Viridans, Streptococci Viridans, Streptococcus Grupo Viridans, Streptococcus do Grupo Viridans
Croatian Not Translated[Viridans Streptococci]
Polish Viridans streptococci
Norwegian Not Translated[Viridans Streptococci]
German Streptococcus-viridans-Gruppe, Viridans-Streptokokken
Russian VIRIDANS STREPTOCOCCI
Dutch Streptococcus-viridansgroep, Viridans streptococci

Ontology: Streptococcus milleri Group (C0318193)

Definition (NCI_CDISC) A bacteria that belongs to the Anginosus group of the genus Streptococcus.
Definition (NCI) A bacterium that belongs to the anginosus group of the genus Streptococcus. This group shows mixed hemolytic properties and can be reactive to a wide variety of Lancefield antigens, which gives these properties little value in the characterization of members of this group.
Definition (NCI) A bacterium that belongs to the Milleri group of the genus Streptococcus.
Definition (NCI_CDISC) A bacteria that belongs to the Milleri group of the genus Streptococcus.
Definition (MSH) A subset of VIRIDANS STREPTOCOCCI, but the species in this group differ in their hemolytic pattern and diseases caused. These species are often beta-hemolytic and produce pyogenic infections.
Concepts Bacterium (T007)
MSH D034364
SnomedCT 415597009, 243246009, 113996008, 127540007
LNC LA20990-0
French Streptocoques du groupe milleri, Groupe des streptocoques milleri
Swedish Streptococcus milleri
Czech Streptococcus - skupina milleri
Portuguese Streptococcus milleri (Grupo), Grupo Streptococcus milleri
English Streptococcus anginosus group (organism), Streptococcus anginosus group, Streptococcus Anginosus Group, Streptococcus Anginosus Group (organism), Streptococcus milleri Group, Streptococcus anginosus Group, Streptococcus milleri group (organism), Streptococcus anginosis milleri group (organism), STREPTOCOCCUS ANGINOSUS GROUP, STREPTOCOCCUS MILLERI GROUP, Streptococcus milleri group [Ambiguous], Streptococcus milleri group, Streptococcus anginosis milleri group
Spanish Streptococcus milleri (Grupo), grupo de Streptococcus anginosis milleri, grupo de Streptococcus milleri, grupo Streptococcus milleri, Streptococcus anginosis, grupo milleri (organismo), grupo Streptococcus milleri (organismo), Streptococcus anginosis, grupo milleri, Grupo Streptococcus milleri, grupo de Streptococcus anginosus (organismo), grupo de Streptococcus anginosus
Finnish Streptococcus milleri -ryhmä
Polish Grupa Streptococcus milleri
Norwegian Not Translated[Streptococcus milleri Group]
German Streptococcus-milleri-Gruppe
Italian Gruppo dello Streptococcus milleri
Russian STREPTOCOCCUS MILLERI GROUP
Dutch Streptococcus-millerigroep

Ontology: Streptococcus salivarius group (C1265299)

Definition (NCI_CDISC) A bacteria that belongs to the Salivarius group of the genus Streptococcus.
Definition (NCI) A bacterium that belongs to the Salivarius group of the genus Streptococcus.
Concepts Bacterium (T007)
SnomedCT 127537007
English Streptococcus salivarius Group, STREPTOCOCCUS SALIVARIUS GROUP, Streptococcus salivarius group (organism), Streptococcus salivarius group
Spanish grupo Streptococcus salivarius (organismo), grupo Streptococcus salivarius