II. Physiology
- Uric Acid is a metabolic-by-product of Purine catabolism
- Uricase converts Uric Acid to allantoin in most mammals, but is dysfunctional in humans
- Uric Acid varies considerably with Purine and Alcohol intake, as well as Renal Function
III. Interpretation: Normal
- Uric Acid: 2-7 mg/dl
IV. Interpretation: Increased (Hyperuricemia)
- See Hyperuricemia
V. Interpretation: Decreased
- Medications
- Allopurinol
- High dose ASA
- Probenecid
- Coumadin
- Corticosteroids
- SIADH
- Renal tubule disease (Fanconi Syndrome)
- Liver disease
- Alcohol
- Wilson's Disease
- Hemochromatosis
- Protein or Purine deficient diet
- Xanthine-oxidase deficiency
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Definition (NCI_NCI-GLOSS) | A waste product left over from normal chemical processes in the body and found in the urine and blood. Abnormal buildup of uric acid in the body may cause a condition called gout. Increased levels of uric acid in the blood and urine can be a side effect of chemotherapy or radiation therapy. |
Definition (NCI) | A white tasteless odorless crystalline product of protein metabolism, found in the blood and urine, as well as trace amounts found in the various organs of the body. It can build up and form stones or crystals in various disease states. |
Definition (MSH) | An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN. |
Definition (ALT) | Uric acid. |
Concepts | Biologically Active Substance (T123) , Organic Chemical (T109) |
MSH | D014527 |
SnomedCT | 1710001 |
English | 2,6,8-Trihydroxypurine, Acid, Uric, Trioxopurine, Uric Acid, 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-, Uric Acid [Chemical/Ingredient], uric acid, 2,6,8-Trioxopurine, 7,9-Dihydro-1H-purine-2,6,8(3H)-trione, 1H-Purine-2,6,8-triol, 2,6,8-Trioxypurine, URIC ACID, Uric acid, UA - Uric acid, Uric acid (substance), Uric acid, NOS, Uricum acidum / uric acid, uricum acidum/uric acid |
Swedish | Urinsyra |
Czech | kyselina močová |
Finnish | Virtsahappo |
Russian | MOCHEVAIA KISLOTA, МОЧЕВАЯ КИСЛОТА |
Japanese | 尿酸 |
Croatian | MOKRAĆNA KISELINA |
Spanish | Ácido Úrico, ácido úrico (sustancia), ácido úrico |
Polish | Kwas moczowy |
French | Acide urique, Urique, acide |
German | Harnsäure |
Italian | Acido urico |
Portuguese | Ácido Úrico |