II. Physiology

  1. Uric Acid is a metabolic-by-product of Purine catabolism
  2. Uricase converts Uric Acid to allantoin in most mammals, but is dysfunctional in humans
  3. Uric Acid varies considerably with Purine and Alcohol intake, as well as Renal Function

III. Interpretation: Normal

  1. Uric Acid: 2-7 mg/dl

IV. Interpretation: Increased (Hyperuricemia)

V. Interpretation: Decreased

  1. Medications
    1. Allopurinol
    2. High dose ASA
    3. Probenecid
    4. Coumadin
    5. Corticosteroids
  2. SIADH
  3. Renal tubule disease (Fanconi Syndrome)
  4. Liver disease
  5. Alcohol
  6. Wilson's Disease
  7. Hemochromatosis
  8. Protein or Purine deficient diet
  9. Xanthine-oxidase deficiency

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