Fractional Excretion of Urea

Aka: Fractional Excretion of Urea, FEUrea

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II. Indications

  1. Acute Kidney Injury
    1. Distinguishes Prerenal Failure from instrinsic Renal Failure (e.g. Acute Tubular Necrosis)
    2. Alternative to Fractional Excretion of Sodium (FENa) as it is not altered by Diuretic use

III. Calculation

  1. Fractional Excretion of Urea (FEUrea in percent) = (sCr * uUrea) / (sUrea x uCr) * 100
  2. Where
    1. sCr: Serum Creatinine
    2. uCr: Urine Creatinine
    3. sUrea: Serum Urea (Blood Urea Nitrogen)
    4. uUrea: Urine Urea

IV. Interpretation: Fractional Excretion of Urea (FEUrea)

  1. FEUrea <35%: Prerenal Failure
  2. FEUrea >50%: Intrinsic renal disease (e.g. Acute Tubular Necrosis)

V. References

  1. Carvounis (2002) Kidney Int 62: 2223-9 [PubMed]

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