II. Epidemiology

  1. Accounts for one third of Nephrotic Syndrome in adults
  2. Peak Incidence 30 to 50 years old

III. Causes

  1. Idiopathic (75%)
  2. Systemic Lupus Erythematosus
  3. Hepatis B Virus Infection
  4. Drug-induced Nephrotic Syndrome
  5. Cancer

IV. Labs

  1. Urinalysis
    1. Microscopic Hematuria (variably present)

V. Labs: Pathology

  1. Thickening of glomerular basement membrane on electron microscopy
  2. IgG and C3 depositis with immunofluorescent stains

VI. Signs

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Ontology: Membranous glomerulonephritis (C0017665)

Definition (CSP) characterized histologically by proteinaceous deposits on the glomerular capillary basement membrane or by thickening of the membrane; clinically similar to chronic glomerulonephritis, occasionally with transient nephrotic syndrome.
Definition (MSH) A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Concepts Disease or Syndrome (T047)
MSH D015433
ICD10 N03.2
SnomedCT 197710000, 77182004
English Extramembranous Glomerulopathy, Glomerulonephritides, Membranous, Glomerulonephritis, Membranous, Glomerulonephropathy, Membranous, Glomerulopathy, Extramembranous, Glomerulopathy, Membranous, Membranous Glomerulonephritides, Membranous Glomerulonephropathy, Membranous Glomerulopathy, Nephropathy, Membranous, Chron neph syn df mbrn glomnph, Chron nephritic syndrom difuse membranous glomerulonephritis, MGN - Membranous GN, MEMBRANOUS GLOMERULOPATHY, Membranous Nephropathy, Membranous glomerulonephropathy, nephropathy membranous, membranous glomerulonephritis, membranous glomerulonephritis (diagnosis), membranous nephropathy (diagnosis), membranous nephropathy, Glomerulonephritis membranous, Membranous nephropathy, Membranous glomerulonephritis, Glomerulonephritis, Membranous [Disease/Finding], glomerulonephritis membranous, membranous glomerulopathy, mgn, membranous glomerulonephropathy, Chronic nephritic syndrome w diffuse membranous glomrlneph, chronic nephritic syndrome with diffuse membranous glomerulonephritis (diagnosis), Chronic nephritic syndrome with diffuse membranous glomerulonephritis, Chronic nephritic syndrome, diffuse membranous glomerulonephritis, MGN - Membranous glomerulonephritis, Membranous glomerulonephritis (disorder), Chronic nephritic syndrome, diffuse membranous glomerulonephritis (disorder), Membranous Glomerulonephritis, Membranous glomerulonephritis NOS, Membranous nephropathy NOS
Dutch membraneuze nefropathie, Chronisch nefritisch syndroom; Diffuse membraneuze glomerulonefritis, glomerulonefritis membraneus, Glomerulonefritis, membraneuze, Membraneuze glomerulonefritis, Membraneuze glomerulopathie, Nefritis, membraneuze glomerulo-, Nefropathie, membraneuze
French Néphropathie membraneuse, Néphropathie glomérulaire extra-membraneuse, Néphropathie glomérulaire extramembraneuse, Glomérulonéphrite extramembraneuse, Glomérulonéphrite extra-membraneuse, Glomérulonéphrite extra-membraneuse (GNEM)
German membranoese Nephropathie, Membranöse Glomerulonephritis, Membranöse Glomerulopathie, Membranöse Nephropathie, Membranöse Glomerulonephropathie, Nephropathie, membranöse, Chronisches nephritisches Syndrom: Diffuse membranoese Glomerulonephritis, Glomerulonephritis membranoes, Glomerulonephritis, membranöse
Portuguese Nefropatia membranosa, GNM, Glomerulonefrite membranosa, Glomerulonefrite Membranosa, Glomerulopatia Membranosa, Nefropatia Membranosa
Spanish Nefropatía membranosa, GNM, glomerulonefritis membranosa (trastorno), glomerulonefritis membranosa, Glomerulonefritis membranosa, Glomerulonefritis Membranosa, Glomerulopatía Membranosa, Nefropatía Membranosa
Swedish Glomerulonefrit, membranös
Japanese マクセイシキュウタイジンエン, マクセイジンショウ, 糸球体腎炎-膜性, 膜性糸球体腎炎, 膜性腎症, 膜様ネフロパシー, 膜様糸球体腎炎
Finnish Membranoosi glomerulonefriitti
Czech Membranózní nefropatie, Membranózní glomerulonefritida, membranózní glomerulonefritida, glomerulonefritida membranózní, membranózní nefropatie, extramembranózní glomerulonefritida
Italian Glomerulonefrite extramembranosa, Glomerulonefropatia membranosa, Nefropatia membranosa, Glomerulopatia membranosa, Glomerulonefrite membranosa
Polish Błoniaste kłębuszkowe zapalenie nerek, Nefropatia błoniasta, Błoniaste zapalenie kłębuszków nerkowych
Hungarian membranosus glomerulonephritis, Membranosus nephropathia
Norwegian Membranøs glomerulonefritt, Glomerulonefritt, membranøs