Rapidly Progressive Glomerulonephritis

Aka: Rapidly Progressive Glomerulonephritis, RPGN

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II. Causes

  1. Glomerulonephritis Causes

III. Symptoms and Signs

  1. Similar to Acute Glomerulonephritis
  2. Rapidly Progressive Renal Failure

IV. Diagnosis: Renal Biopsy

  1. Crescentic Glomerulonephritis

V. Course

  1. Progresses to Renal Failure within weeks to months
  2. Patients refusing Dialysis within 6 months: 50%

VI. Management

  1. Pulsed dose Glucocorticoids
  2. Cytotoxic agents
    1. Azathioprine
    2. Cyclophosphamide
  3. Plasma Exchange

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