II. Epidemiology
- Patients under age 30 years
- Affects 3 to 5% of adults and teenagers
- Most common cause of Pediatric Proteinuria (especially in adolescent males)
III. Pathophysiology
IV. Labs
- Split spot urine tests (with Urine Dipstick or Urine Protein to Creatinine Ratio)
- Normal Urine Protein on spot urine test of first morning void (after supine throughout the night)
- Increased Urine Protein after upright for at least 4-6 hours
- Urine Dipstick positive for Urine Protein OR
- Urine Protein to Creatinine Ratio >0.2
-
Split 24 Hour Urine Protein collection
- Urine Protein decreases to <50 mg for 8 hours supine
-
Urine Protein 24 Hour collection
- Less than 2000 mg Protein excretion per day
- Other urine and renal tests normal
- Renal Function tests (normal Creatinine Clearance, GFR)
- Urine microscopy normal (no Urine RBC or Urine WBC)
V. Differential Diagnosis
VI. Monitoring
- Blood Pressure yearly
- Urinalysis yearly
VII. Prognosis
- Benign condition with no longterm Renal Function affect