II. Indications
- Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
- Cutaneous Candidiasis
III. Contraindications
- Not FDA approved in children
IV. Mechanism
- Imidazole Antifungal
- As with other azoles, inhibits the synthesis of ergosterol (key component of fungal cell wall)
- Blocks sterol 14-a-dimethylase (microsomal Cytochrome P450-dependent enzyme)
- Other activity specific to Econazole
- Endogenous respiration inhibitor
- Purine uptake inhibitor
- Phospholipid synthesis inhibitor
V. Medications
- Cream: 1%
- Foam: 1%
VI. Dosing: Superficial dermatophyte infections and Candidiasis
- Apply once daily for dermatophyte infections for 2 weeks (4 weeks for Tinea Pedis)
- Apply twice daily for Cutaneous Candidiasis for 2 weeks
VII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
VIII. Drug Interactions
- Unlikely Drug Interactions given minimal absorption
-
Warfarin
- May increase INR
IX. Resources
- Econazole Cream (DailyMed)
- Econazole Foam (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
| econazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ECONAZOLE NITRATE 1% CREAM | Generic | $0.39 per gram |