II. Indications

  1. Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
  2. Cutaneous Candidiasis

III. Contraindications

  1. Not FDA approved in children

IV. Mechanism

  1. Imidazole Antifungal
  2. As with other azoles, inhibits the synthesis of ergosterol (key component of fungal cell wall)
    1. Blocks sterol 14-a-dimethylase (microsomal Cytochrome P450-dependent enzyme)
  3. Other activity specific to Econazole
    1. Endogenous respiration inhibitor
    2. Purine uptake inhibitor
    3. Phospholipid synthesis inhibitor

V. Medications

  1. Cream: 1%
  2. Foam: 1%

VI. Dosing: Superficial dermatophyte infections and Candidiasis

  1. Apply once daily for dermatophyte infections for 2 weeks (4 weeks for Tinea Pedis)
  2. Apply twice daily for Cutaneous Candidiasis for 2 weeks

VII. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

VIII. Drug Interactions

  1. Unlikely Drug Interactions given minimal absorption
  2. Warfarin
    1. May increase INR

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

econazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ECONAZOLE NITRATE 1% CREAM Generic $0.39 per gram