II. Indications

  1. Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
  2. Cutaneous Candidiasis

III. Contraindications

  1. Not FDA approved in children

IV. Mechanism

  1. Imidazole Antifungal
  2. As with other azoles, inhibits the synthesis of ergosterol (key component of fungal cell wall)
    1. Blocks sterol 14-a-dimethylase (microsomal Cytochrome P450-dependent enzyme)
  3. Other activity specific to Econazole
    1. Endogenous respiration inhibitor
    2. Purine uptake inhibitor
    3. Phospholipid synthesis inhibitor

V. Medications

  1. Cream: 1%
  2. Foam: 1%

VI. Dosing: Superficial dermatophyte infections and Candidiasis

  1. Apply once daily for dermatophyte infections for 2 weeks (4 weeks for Tinea Pedis)
  2. Apply twice daily for Cutaneous Candidiasis for 2 weeks

VII. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

VIII. Drug Interactions

  1. Unlikely Drug Interactions given minimal absorption
  2. Warfarin
    1. May increase INR

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Related Studies

Cost: Medications

econazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ECONAZOLE NITRATE 1% CREAM Generic $0.39 per gram

Ontology: Econazole (C0013547)

Definition (MSH) An imidazole derivative that is commonly used as a topical antifungal agent.
Definition (NCI) An imidazole with antifungal property. Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase, which catalyzes conversion of lanosterol to ergosterol, an essential component of the fungal cell wall. As a result, this agent increases cellular permeability thereby resulting in leakage of cellular contents. Furthermore, econazole has also been implicated to inhibit endogenous respiration, interact with membrane phospholipids, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004464
SnomedCT 18952006, 373471002
LNC LP20809-7, MTHU012383
English Econazole, Ekonazole, 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, Econazole [Chemical/Ingredient], ekonazole, econazole, ECONAZOLE, Econazole (product), Econazole (substance)
Swedish Ekonazol
Czech ekonazol
Finnish Ekonatsoli
Russian EKONAZOL, EKONAZOLNITRAT, ЭКОНАЗОЛ, ЭКОНАЗОЛНИТРАТ
Japanese パラベール, 硝酸エコナゾール, エコナゾール, エコナゾール硝酸塩
Polish Ekonazol
Spanish econazol (producto), econazol (sustancia), econazol, Econazol
French Éconazole
German Econazol
Italian Econazolo
Portuguese Econazol

Ontology: Spectazole (C0723418)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Spectazole, spectazole