II. Indications
- Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
- Cutaneous Candidiasis
III. Contraindications
- Not FDA approved in children
IV. Mechanism
- Imidazole Antifungal
- As with other azoles, inhibits the synthesis of ergosterol (key component of fungal cell wall)
- Blocks sterol 14-a-dimethylase (microsomal Cytochrome P450-dependent enzyme)
- Other activity specific to Econazole
- Endogenous respiration inhibitor
- Purine uptake inhibitor
- Phospholipid synthesis inhibitor
V. Medications
- Cream: 1%
- Foam: 1%
VI. Dosing: Superficial dermatophyte infections and Candidiasis
- Apply once daily for dermatophyte infections for 2 weeks (4 weeks for Tinea Pedis)
- Apply twice daily for Cutaneous Candidiasis for 2 weeks
VII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
VIII. Drug Interactions
- Unlikely Drug Interactions given minimal absorption
-
Warfarin
- May increase INR
IX. Resources
- Econazole Cream (DailyMed)
- Econazole Foam (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
econazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
ECONAZOLE NITRATE 1% CREAM | Generic | $0.39 per gram |
Ontology: Econazole (C0013547)
Definition (MSH) | An imidazole derivative that is commonly used as a topical antifungal agent. |
Definition (NCI) | An imidazole with antifungal property. Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase, which catalyzes conversion of lanosterol to ergosterol, an essential component of the fungal cell wall. As a result, this agent increases cellular permeability thereby resulting in leakage of cellular contents. Furthermore, econazole has also been implicated to inhibit endogenous respiration, interact with membrane phospholipids, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D004464 |
SnomedCT | 18952006, 373471002 |
LNC | LP20809-7, MTHU012383 |
English | Econazole, Ekonazole, 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, Econazole [Chemical/Ingredient], ekonazole, econazole, ECONAZOLE, Econazole (product), Econazole (substance) |
Swedish | Ekonazol |
Czech | ekonazol |
Finnish | Ekonatsoli |
Russian | EKONAZOL, EKONAZOLNITRAT, ЭКОНАЗОЛ, ЭКОНАЗОЛНИТРАТ |
Japanese | パラベール, 硝酸エコナゾール, エコナゾール, エコナゾール硝酸塩 |
Polish | Ekonazol |
Spanish | econazol (producto), econazol (sustancia), econazol, Econazol |
French | Éconazole |
German | Econazol |
Italian | Econazolo |
Portuguese | Econazol |
Ontology: Spectazole (C0723418)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
English | Spectazole, spectazole |