II. Indications
- Plaque Psoriasis (FDA approved for age >=12 years)
- Other off label uses
- Morphea
- Vitiligo
- Darier Disease
III. Mechanism
- Calcipotriene (Calcipotriol) is a synthetic Vitamin D derivative primarily used for Psoriasis
- Calcipotriene competes with 1,25 hydroxy-Vitamin D at receptors that regulate cell proliferation and differentiation
- Suppresses Keratinocyte proliferation, helping to normalize epidermal growth
IV. Medications
- Calcipotriene Cream 0.005%
- Calcipotriene Ointment 0.005%
- Calcipotriene Scalp Solution 0.005%
- Calcipotriene Foam 0.005%
V. Dosing
- For adults and children age >=12 years
- Ointment applied twice daily to involved regions of scalp and body (NOT the face)
VI. Efficacy
- Begin to see benefit in 2 weeks
- Maximum benefit in 6-8 weeks
- Resolution in 10% of patients
- Moderate Improvement in 70% of patients
- No Improvement in 20% of patients
- Useful adjunct to PUVA
VII. Adverse Effects
-
Contact Dermatitis (allergic or irritant, occurs in up to 10-15% of patients)
- Local irritation, burning, itching (esp. in the skin folds)
- Do not use on face
-
Hypercalcemia
- Calcipotriene is a Vitamin D analog with risk of Hypercalcemia
- Limit Calcipotriene to 100 grams per week
VIII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
IX. Resources
- Calcipotriene Ointment (DailyMed)
- Calcipotriene Cream (DailyMed)
- Calcipotriene Solution (DailyMed)
- Calcipotriene Foam (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
| calcipotriene (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CALCIPOTRIENE 0.005% CREAM | Generic | $1.02 per gram |
| CALCIPOTRIENE 0.005% OINTMENT | Generic | $2.14 per gram |
| CALCIPOTRIENE 0.005% SOLUTION | Generic | $0.97 per ml |
| CALCIPOTRIENE-BETAMETH DP OINT | Generic | $4.02 per gram |
| CALCIPOTRIENE-BETAMETHASONE DP 0.005%-0.064% SUSPENSION | Generic | $3.10 per gram |