II. Indications
- Plaque Psoriasis (FDA approved for age >=12 years)
- Other off label uses
- Morphea
- Vitiligo
- Darier Disease
III. Mechanism
- Calcipotriene (Calcipotriol) is a synthetic Vitamin D derivative primarily used for Psoriasis
- Calcipotriene competes with 1,25 hydroxy-Vitamin D at receptors that regulate cell proliferation and differentiation
- Suppresses Keratinocyte proliferation, helping to normalize epidermal growth
IV. Medications
- Calcipotriene Cream 0.005%
- Calcipotriene Ointment 0.005%
- Calcipotriene Scalp Solution 0.005%
- Calcipotriene Foam 0.005%
V. Dosing
- For adults and children age >=12 years
- Ointment applied twice daily to involved regions of scalp and body (NOT the face)
VI. Efficacy
- Begin to see benefit in 2 weeks
- Maximum benefit in 6-8 weeks
- Resolution in 10% of patients
- Moderate Improvement in 70% of patients
- No Improvement in 20% of patients
- Useful adjunct to PUVA
VII. Adverse Effects
-
Contact Dermatitis (allergic or irritant, occurs in up to 10-15% of patients)
- Local irritation, burning, itching (esp. in the skin folds)
- Do not use on face
-
Hypercalcemia
- Calcipotriene is a Vitamin D analog with risk of Hypercalcemia
- Limit Calcipotriene to 100 grams per week
VIII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
IX. Resources
- Calcipotriene Ointment (DailyMed)
- Calcipotriene Cream (DailyMed)
- Calcipotriene Solution (DailyMed)
- Calcipotriene Foam (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
calcipotriene (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
CALCIPOTRIENE 0.005% CREAM | Generic | $1.02 per gram |
CALCIPOTRIENE 0.005% OINTMENT | Generic | $2.14 per gram |
CALCIPOTRIENE 0.005% SOLUTION | Generic | $0.97 per ml |
CALCIPOTRIENE-BETAMETH DP OINT | Generic | $4.02 per gram |
CALCIPOTRIENE-BETAMETHASONE DP 0.005%-0.064% SUSPENSION | Generic | $3.10 per gram |
Ontology: calcipotriene (C0065767)
Definition (NCI) | A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C055085 |
SnomedCT | 108910005, 126232005, 395766004 |
English | 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1alpha,3beta,5Z,7E,22E)-, calcipotriol, 1,24(OH)2-22-ene-24-cyclopropyl D3, calcipotriene, calcipotriene (medication), CALCIPOTRIENE, calcipotriene [Chemical/Ingredient], Calcipotriene (product), Calcipotriol, Calcipotriene preparation (product), Calcipotriene preparation, Calcipotriol (substance), Calcipotriene (substance), Calcipotriene preparation (substance), Calcipotriene |
Spanish | calcipotrieno (producto), calcipotrieno, preparado con calcipotrieno (producto), preparado con calcipotrieno, calcipotrieno (sustancia), calcipotriol (sustancia), calcipotriol, preparado de calcipotrieno (producto), preparado de calcipotrieno (sustancia), preparado de calcipotrieno |