II. Indications
- Resistant dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
- FDA approved in adults and children over age 12 years old
- As an exception, FDA approved for Tinea Cruris down to age >2 years
III. Mechanism
- Topical synthetic allylamine (similar to Terbinafine)
- Broad-spectrum Antifungal activity
- Blocks Ergosterol synthesis (key component in the fungal cell wall)
- Inhibits squalene epoxidase, the enzyme that converts squalene to ergosterol
IV. Medications: Topical
- Naftifine HCl (Naftin)
- Cream: 1%, 2%
- Gel: 1%, 2%
V. Dosing
- Apply cream once daily (or gel twice daily) for up to 4 weeks
VI. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VII. Efficacy
- Effective in refractory cases of superficial Tinea Infections
- Less effective in Cutaneous Candidiasis
VIII. Resources
- Naftifine Gel (DailyMed)
- Naftifine Cream (DailyMed)
IX. References
Images: Related links to external sites (from Bing)
Related Studies
| naftifine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| NAFTIFINE HCL 2% CREAM | Generic | $2.87 per gram |
| naftin (on 1/6/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| NAFTIN 2% GEL | $9.76 per gram | |