II. Indications
- Resistant dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
- FDA approved in adults and children over age 12 years old
- As an exception, FDA approved for Tinea Cruris down to age >2 years
III. Mechanism
- Topical synthetic allylamine (similar to Terbinafine)
- Broad-spectrum Antifungal activity
- Blocks Ergosterol synthesis (key component in the fungal cell wall)
- Inhibits squalene epoxidase, the enzyme that converts squalene to ergosterol
IV. Medications: Topical
- Naftifine HCl (Naftin)
- Cream: 1%, 2%
- Gel: 1%, 2%
V. Dosing
- Apply cream once daily (or gel twice daily) for up to 4 weeks
VI. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VII. Efficacy
- Effective in refractory cases of superficial Tinea Infections
- Less effective in Cutaneous Candidiasis
VIII. Resources
- Naftifine Gel (DailyMed)
- Naftifine Cream (DailyMed)
IX. References
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Related Studies
naftifine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
NAFTIFINE HCL 2% CREAM | Generic | $2.87 per gram |
naftin (on 1/6/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
NAFTIN 2% GEL | $9.76 per gram |
Ontology: naftifine (C0068367)
Definition (NCI) | A topical, synthetic allylamine derivate similar to terbinafine with broad-spectrum antifungal activity. Naftifine can be fungicidal or fungistatic depending on the concentration and the organisms involved. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C029178 |
SnomedCT | 13800009, 372655002 |
English | 1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, (E)-, naftifin, naftifine, naftifine [Chemical/Ingredient], NAFTIFINE, Naftifine, Naftifine (product), Naftifine (substance) |
Spanish | naftifina (producto), naftifina (sustancia), naftifina |
Ontology: Naftin (C0721922)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
English | Naftin, naftin |