II. Indications

  1. Resistant dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
    1. FDA approved in adults and children over age 12 years old
    2. As an exception, FDA approved for Tinea Cruris down to age >2 years

III. Mechanism

  1. Topical synthetic allylamine (similar to Terbinafine)
  2. Broad-spectrum Antifungal activity
  3. Blocks Ergosterol synthesis (key component in the fungal cell wall)
    1. Inhibits squalene epoxidase, the enzyme that converts squalene to ergosterol

IV. Medications: Topical

  1. Naftifine HCl (Naftin)
    1. Cream: 1%, 2%
    2. Gel: 1%, 2%

V. Dosing

  1. Apply cream once daily (or gel twice daily) for up to 4 weeks

VI. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

VII. Efficacy

  1. Effective in refractory cases of superficial Tinea Infections
  2. Less effective in Cutaneous Candidiasis

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Related Studies

Cost: Medications

naftifine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
NAFTIFINE HCL 2% CREAM Generic $2.87 per gram
naftin (on 1/6/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
NAFTIN 2% GEL $9.76 per gram

Ontology: naftifine (C0068367)

Definition (NCI) A topical, synthetic allylamine derivate similar to terbinafine with broad-spectrum antifungal activity. Naftifine can be fungicidal or fungistatic depending on the concentration and the organisms involved.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C029178
SnomedCT 13800009, 372655002
English 1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, (E)-, naftifin, naftifine, naftifine [Chemical/Ingredient], NAFTIFINE, Naftifine, Naftifine (product), Naftifine (substance)
Spanish naftifina (producto), naftifina (sustancia), naftifina

Ontology: Naftin (C0721922)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Naftin, naftin