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Definition (NCI)
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A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.
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Definition (MSH)
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A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
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Definition (CSP)
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4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2- benzothiazine-3-carboxamide- 1,1-dioxide; nonsteroidal antiinflammatory drug (NSAID) which functions by inhibiting prostaglandin synthesis; effective against colon cancer.
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Definition (PDQ)
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A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39761&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39761&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C751" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D010894
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| SnomedCT |
363618008, 27754002, 387153005 |
| LNC |
LP15181-8, MTHU001848 |
| English |
Piroxicam, 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide, 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboximide-1,1-dioxide, piroxicam, PXM, piroxicam (medication), PIROXICAM, Piroxicam [Chemical/Ingredient], Piroxicam product (substance), Piroxicam product, Piroxicam (product), Piroxicam (substance) |
| Swedish |
Piroxikam
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| Czech |
piroxikam
|
| Finnish |
Piroksikaami
|
| Russian |
PIROKSIKAM, ПИРОКСИКАМ |
| Japanese |
ピオパール, フェルデン, バキソ, ピロキシカム |
| Croatian |
PIROKSIKAM
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| Polish |
Piroksykam
|
| Spanish |
piroxicam (producto), piroxicam (sustancia), piroxicam, Piroxicam |
| French |
Piroxicam
|
| German |
Piroxicam
|
| Italian |
Piroxicam
|
| Portuguese |
Piroxicam
|
