II. Indications

III. Mechanism

  1. Derived from jalapeno peppers
  2. Depletes Substance P from pain fibers
  3. Requires frequent and repeat applications for affect
  4. Inconsistent use not effective

IV. Dose: Capsaicin Cream (OTC)

  1. Apply Capsaicin cream (0,025% to 0.075%) to affected area 3-5 times daily

V. Dose: Capsaicin Patch (high dose - 8%)

  1. Applied in office
  2. Pre-treat area by applying 4% Lidocaine cream for 60 minutes
  3. Check area for anesthesia following application
  4. Apply Capsaicin 8% cream with gloves and leave on for 60 minutes
  5. Wash off after 1 hour

VI. Adverse effects

  1. Burning sensation on initial application
  2. Increased pain for up to first week of application

VII. Precautions

  1. Wash hands thoroughly after Capsaicin application

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Cost: Medications

capsaicin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CAPSAICIN 0.025% CREAM Generic OTC $0.07 per gram

Ontology: Capsaicin (C0006931)

Definition (NCI_NCI-GLOSS) A component of certain plants, including cayenne and red pepper, used topically for peripheral nerve pain. Also being studied for controlling mucositis pain after chemotherapy and radiation therapy.
Definition (NCI) A chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis.
Definition (NCI_CRCH) Capsaicinoid compound with side chain CO(CH2)4(CH)2CH(CH3)2. The chemical structure is CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC.
Definition (CSP) N-(4-hydroxy-3-methoxyphenylmethyl) -8-methyl-6-nonenamide; chili pepper extract and neuropeptide releasing agent selective for primary sensory peripheral neurons, used to experimentally manipulate substance P and other tachykinins, and as an analgesic for Herpes zoster infection.
Definition (MSH) An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Concepts Pharmacologic Substance (T121) , Lipid (T119)
MSH D002211
SnomedCT 400416009, 95995002
English 8-Methyl-N-Vanillyl-6-Nonenamide, Capsaicin, Capsaicine, 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-, (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide, N-(4-hydroxy-3-methoxyphenylmethyl) -8-Methyl-6-Nonenamide, 8 Methyl N Vanillyl 6 Nonenamide, CAPSAICIN, capsaicin, Capsaicin [Chemical/Ingredient], capsaicine, (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide, Capsaicin (product), Capsaicin (substance)
Swedish Kapsaicin
Czech kapsaicin
Finnish Kapsaisiini
German Trans-8-Methyl-N-vanillyl- 6-nonensäureamid, Capsaicin
Japanese カプサイシン
French N-(4-Hydroxy-3-méthoxybenzyl)-8-méthylnon-6-énamide, 8-Méthyl-N-vanillyl-non-6-énamide, N-(4-Hydroxy-3-méthoxybenzyl)-8-méthyl-non-6-énamide, Capsaïcine
Polish Kapsaicyna
Spanish capsaicina (producto), capsaicina (sustancia), capsaicina, Capsaicina
Italian Capsaicina
Portuguese Capsaicina

Ontology: Zostrix (C0308191)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002211
English Zostrix Neuropathy, zostrix, Link Brand of Capsaicin, Medicis Brand of Capsaicin, Zostrix