Salsalate

Aka: Salsalate, Salflex, Disalcid, Amigesic

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II. Indications

  1. FDA approved indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis

III. Contraindications

  1. See Salicylate

IV. Mechanism

  1. See Salicylate
  2. Salsalate is a prodrug that is hydrolyzed to the active salicylic acid
  3. Salsalate additional function
    1. Inhibits nuclear factor-kappa B (NF-kB) suppressing gene expression related to inflammation

V. Dosing

  1. Arthritis (OA, RA): 3000 mg/day divided every 8 to 12 hours

VI. Adverse Effects

  1. See Salicylate

VII. Safety

  1. See Salicylate
  2. Unknown Safety in Lactation

VIII. Resources

  1. Salsalate (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cef8d6d6-a4e8-4502-8e2f-7cd5129a434c

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