Salsalate

Aka: Salsalate, Salflex, Disalcid, Amigesic

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II. Indications

  1. FDA approved indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis

III. Contraindications

  1. See Salicylate

IV. Mechanism

  1. See Salicylate
  2. Salsalate is a prodrug that is hydrolyzed to the active salicylic acid
  3. Salsalate additional function
    1. Inhibits nuclear factor-kappa B (NF-kB) suppressing gene expression related to inflammation

V. Dosing

  1. Arthritis (OA, RA): 3000 mg/day divided every 8 to 12 hours

VI. Adverse Effects

  1. See Salicylate

VII. Safety

  1. See Salicylate
  2. Unknown Safety in Lactation

VIII. Resources

  1. Salsalate (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cef8d6d6-a4e8-4502-8e2f-7cd5129a434c

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Cost: Medications

salsalate (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SALSALATE 750 MG TABLET Generic $0.31 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Analgesic Medications

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