II. Indications
- FDA approved indications in adults
III. Contraindications
- See Salicylate
IV. Mechanism
- See Salicylate
- Salsalate is a prodrug that is hydrolyzed to the active salicylic acid
- Salsalate additional function
- Inhibits nuclear factor-kappa B (NF-kB) suppressing gene expression related to inflammation
V. Dosing
- Arthritis (OA, RA): 3000 mg/day divided every 8 to 12 hours
VI. Adverse Effects
- See Salicylate
VII. Safety
- See Salicylate
- Unknown Safety in Lactation
VIII. Resources
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Related Studies
| salsalate (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| SALSALATE 750 MG TABLET | Generic | $0.31 each |
Ontology: Salsalate (C0073983)
| Definition (NCI) | An orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. As a prodrug, salsalate is hydrolyzed to salicylic acid which inhibits the expression of cyclooxygenase (COX) enzymes. This prevents the conversion of arachidonic acid into prostaglandin precursors and leads to decreased formation of prostaglandins that are involved in pain, fever and inflammation. In addition, salsalate appears to inhibit nuclear factor-kappa B (NF-kB), thereby preventing activation of the NF-kB-mediated pathway and the expression of genes involved in inflammation. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C014182 |
| SnomedCT | 363633000, 13252002, 387072007 |
| English | disalicylic acid, salicylsalicylic acid, salsalate, Salicylsalicylic Acid, o-Salicylsalicylic Acid, Benzoic Acid, 2-Hydroxy-, 2-Carboxyphenyl Ester, salsalate (medication), salicylsalicylic acid (medication), salicylsalicylic acid [Chemical/Ingredient], SALSALATE, Salsalate product, Salsalate product (substance), Salicylsalicylic acid product, Disalicylic acid, Salicylsalicylic acid, Salsalate (product), Salsalate (substance), Salsalate, NOS, Salsalate |
| Japanese | サルサラート |
| Spanish | salsalato (producto), salsalato (sustancia), salsalato, ácido disalicílico, ácido salicilsalicílico |
