II. Indications

  1. FDA approved indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis

III. Contraindications

IV. Mechanism

  1. See Salicylate
  2. Salsalate is a prodrug that is hydrolyzed to the active salicylic acid
  3. Salsalate additional function
    1. Inhibits nuclear factor-kappa B (NF-kB) suppressing gene expression related to inflammation

V. Dosing

  1. Arthritis (OA, RA): 3000 mg/day divided every 8 to 12 hours

VI. Adverse Effects

VII. Safety

  1. See Salicylate
  2. Unknown Safety in Lactation

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Related Studies

Cost: Medications

salsalate (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SALSALATE 750 MG TABLET Generic $0.31 each