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Ontology:
Ketorolac
(C0073631)
Definition (NCI)
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A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.
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Definition (MSH)
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A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
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Definition (PDQ)
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A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. Ketorolac, a non-selective inhibitor of the cyclo-oxygenase (COX) enzyme, prevents the synthesis of prostaglandins and thromboxanes from arachidonic acid. COX enzymes exist in two isoforms; inhibition of the COX-2 enzyme produces the anti-inflammatory and analgesic whereas, inhibition of the COX-1 enzyme is associated with gastrointestinal side effects, nephrotoxicity and platelet de-aggregatory effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40569&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40569&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1219" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D020910
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SnomedCT |
363609006, 108512006, 372501008 |
LNC |
LP18986-7, MTHU007199 |
English |
Ketorolac, 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro, Ketorolac [Chemical/Ingredient], Ketorolac product (substance), Ketorolac product, KETOROLAC, anti-inflammatory nonsteroidal ketorolac, ketorolac (medication), ketorolac, Ketorolac (product), Ketorolac (substance) |
Swedish |
Ketorolak
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Czech |
ketorolak
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Finnish |
Ketorolaakki
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Russian |
KETOROLAK, КЕТОРОЛАК |
Spanish |
ketorolac (producto), cetorolaco, ketorolaco (producto), ketorolac, ketorolac (sustancia), ketorolaco (sustancia), ketorolaco, Ketorolaco |
Polish |
Ketorolak
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French |
Kétorolac
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German |
Ketorolac
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Italian |
Ketorolac
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Portuguese |
Cetorolaco
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Ontology:
Toradol
(C0146226)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D020911
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English |
Toradol, toradol |