Trisalicylate

Aka: Trisalicylate, Choline Magnesium Trisalicylate

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II. Indications

  1. FDA approved indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis
    3. Analgesic in mild to moderate pain

III. Contraindications

  1. See Salicylate

IV. Mechanism

  1. See Salicylate
  2. Nonacetylated dimer of salicylic acid

V. Dosing: Adults

  1. Arthritis (RA, OA): 750 to 1500 mg orally twice daily
  2. Also found in OTC combination products

VI. Adverse Effects

  1. See Salicylate
  2. Hepatotoxicity

VII. Safety

  1. See Salicylate
  2. Unknown Safety in Lactation

VIII. Resources

  1. Choline Magnesium Trisalicylate combined with Caffeine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c69f3c8f-d467-4e45-a94a-fc959b0f2f13
  2. Trisalicylate (Liver Tox)
    1. https://www.ncbi.nlm.nih.gov/books/NBK547963/

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