II. Indications
- See NSAID
- FDA Approved Indications in adults
- FDA Approved Indications in children
III. Contraindications
- See NSAID
V. Medications
- Tolmetin (Tolectin)
- Tablets: 200 mg (scored), 600 mg
- Capsules: 400 mg
VI. Dosing: Adult
- Start 200 to 400 mg orally three times daily
- May increase to 600 mg orally three times daily
- Maximum: 1800 mg/day
VII. Dosing: Child (age >= 2 years old)
-
Juvenile Rheumatoid Arthritis
- Start: 20 mg/kg/day orally divided three to four times daily
- Range: 15 to 30 mg/kg/day divided three to four times daily
- Maximum: 2000 mg/24 hours
VIII. Adverse Effects
- See NSAID
- Anaphylaxis
IX. Safety
X. Resources
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Related Studies
| Definition (NCI) | An arylalkanoic acid and non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic activities. Although the exact mechanism through which tolmetin exerts its effects has yet to be fully elucidated, this agent appears to inhibit the enzyme prostaglandin synthase. This prevents the formation of prostaglandins from prostaglandin precursors, including the synthesis of the inflammatory prostaglandin E2 (PGE2) from the precursor prostaglandin H2 (PGH2). This prevents prostaglandin-mediated effects, including pain, inflammation and fever. |
| Definition (MSH) | A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D014046 |
| SnomedCT | 363628004, 372748008, 45680002 |
| LNC | LP18114-6, MTHU003398 |
| English | Tolmetin, 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, Tolmetin [Chemical/Ingredient], Tolmetin product (substance), Tolmetin product, TOLMETIN, tolmetin, Tolmetin (product), Tolmetin (substance) |
| Swedish | Tolmetin |
| Czech | tolmetin |
| Finnish | Tolmetiini |
| Russian | TOLMETIN, ТОЛМЕТИН |
| Japanese | トルメチン |
| Polish | Tolmetin |
| Spanish | tolmetina (producto), tolmetina (sustancia), tolmetina, Tolmetina |
| French | Tolmétine |
| German | Tolmetin |
| Italian | Tolmetina |
| Portuguese | Tolmetino |
