Etodolac

Aka: Etodolac, Lodine

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II. Indications

  1. See NSAID
  2. FDA approved for Osteoarthritis, Rheumatoid Arthritis and as a general anaglesic for mild to moderate pain

III. Contraindications

  1. See NSAID

IV. Mechanism

  1. See NSAID
  2. Partially COX2-selective (with less GI side effects), similar to Nabumetone (Relafen)

V. Medications

  1. Etodolac (Lodine) - Immediate Release: 200 mg, 300 mg, 400 mg, 500 mg capsules and tablets
  2. Etodolac XL (Lodine XL) - Extended Release: 400 mg, 500 mg and 600 mg tablets

VI. Dosing

  1. Etodolac (Lodine)
    1. Dose 200 to 400 mg orally twice to three times daily
  2. Etodolac XL (Lodine XL)
    1. Dose: 400 to 1200 mg orally daily

VII. Adverse Effects

  1. See NSAID

VIII. Safety

  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)

IX. Efficacy

  1. Etodolac 400 mg is superior to Aspirin 650 mg as an Analgesic

X. Resources

  1. Etodolac (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ec82b108-6a6f-4d1b-82cb-831d4ed36c80
  2. Etodolac XL - Extended Release (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f3bf1675-8fda-40d3-8427-0a6a6133a3d3

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Related Studies

Cost: Medications

etodolac (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ETODOLAC 200 MG CAPSULE Generic $0.70 each
ETODOLAC 300 MG CAPSULE Generic $0.49 each
ETODOLAC 400 MG TABLET Generic $0.29 each
ETODOLAC 500 MG TABLET Generic $0.26 each
ETODOLAC ER 400 MG TABLET Generic $1.17 each
ETODOLAC ER 500 MG TABLET Generic $1.26 each
ETODOLAC ER 600 MG TABLET Generic $2.05 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Analgesic Medications

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