Definition (NCI)
|
The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.
|
Definition (NCI_NCI-GLOSS)
|
A drug used to relieve pain.
|
Definition (MSH)
|
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D004091
|
SnomedCT |
387485001, 44508008, 414428000, 83929000 |
LNC |
LP16162-7, MTHU007189 |
English |
Dihydromorphinone, Hydromorphon, Hydromorphone, Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-, hydromorphone (medication), Hydromorphone [Chemical/Ingredient], HYDROMORPHONE, HYDROmorphone, (-)-Hydromorphone, hydromorphone, Hydromorphone (substance), dihydromorphinone, hydromorphon, Hydromorphone (product) |
Swedish |
Hydromorfon
|
Spanish |
dihidromorfinona, Hidromorfona, hidromorfona (sustancia), hidromorfona, hidromorfona (producto), Dihidromorfinona |
Czech |
dihydromorfinon
|
Finnish |
Hydromorfoni
|
Russian |
DIGIDROMORFINON, GIDROMORFON, LAUDAKON, ГИДРОМОРФОН, ДИГИДРОМОРФИНОН, ЛАУДАКОН |
Japanese |
ヒドロモルフォン, ラウダコン, ジヒドロモルフィノン, ヒドロモルホン |
Italian |
Diidromorfinone, Idromorfone |
Polish |
Hydromorfon, Dwuhydromorfinon, Dihydromorfinon, Dilavdit, Lavdacon |
Portuguese |
Di-Hidromorfinona, Hidromorfona |
French |
Dihydromorphinone
|
German |
Dihydromorphinon, Hydromorphone, Hydromorphon |