II. Definitions

  1. Integrin
    1. Integrins are cell surface Glycoprotein receptors with alpha and beta subunits
    2. Integrins are involved in Leukocyte adhesion, signaling, proliferation, and migration
  2. Integrin Alpha4
    1. Unique subunit to Integrins
  3. Integrin Receptor Antagonist
    1. Monoclonal antibodies against Integrin (binds alpha 4 subunit)
    2. Prevents immune cell migration in Autoimmune Disease

III. Medications: Integrin Receptor Antagonists

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