Integrin Receptor Antagonist

Aka: Integrin Receptor Antagonist, Integrin Alpha4, Integrin

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II. Definitions

  1. Integrin
    1. Integrins are cell surface Glycoprotein receptors with alpha and beta subunits
    2. Integrins are involved in Leukocyte adhesion, signaling, proliferation, and migration
  2. Integrin Alpha4
    1. Unique subunit to Integrins
  3. Integrin Receptor Antagonist
    1. Monoclonal antibodies against Integrin (binds alpha 4 subunit)
    2. Prevents immune cell migration in Autoimmune Disease

III. Medications: Integrin Receptor Antagonists

  1. Vedolizumab (Entyvio)
    1. Indicated in active Inflammatory Bowel Disease (Crohns Disease, Ulcerative Colitis)
  2. Natalizumab (Tysabri)
    1. Indicated in Multiple Sclerosis and refractory Crohns Disease

IV. References

  1. Dotan (2020) Med Res Rev 40(1):245-62 +PMID: 31215680 [PubMed]

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