II. Definitions
- Integrin
- Integrins are cell surface Glycoprotein receptors with alpha and beta subunits
- Integrins are involved in Leukocyte adhesion, signaling, proliferation, and migration
- Integrin Alpha4
- Unique subunit to Integrins
- Integrin Receptor Antagonist
- Monoclonal antibodies against Integrin (binds alpha 4 subunit)
- Prevents immune cell migration in Autoimmune Disease
III. Medications: Integrin Receptor Antagonists
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Vedolizumab (Entyvio)
- Indicated in active Inflammatory Bowel Disease (Crohns Disease, Ulcerative Colitis)
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Natalizumab (Tysabri)
- Indicated in Multiple Sclerosis and refractory Crohns Disease
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Definition (NCI) | Integrins are transmembrane glycoprotein receptors that mediate cell-matrix or cell-cell adhesion, and transduce signals that regulate gene expression and cell growth. They are heterodimeric molecules consisting of noncovalently linked alpha and beta subunits. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Both alpha and beta subunits display a cytoplasmic domain that interacts with the cytoskeleton (and possibly signaling molecules), a transmembrane region, and a large extracellular domain that interacts with the extracellular matrix. (from OMIM 147557) |
Definition (CSP) | family of integral membrane proteins which serve as receptors for fibronectin, laminin, and other adhesive extracellular glycoproteins. |
Definition (MSH) | A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. |
Concepts | Receptor (T192) , Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
MSH | D016023 |
Swedish | Integriner |
Czech | integriny |
Finnish | Integriinit |
Russian | RETSEPTORY, KLETOCHNOI ADGEZII BELOK, INTEGRINY, ИНТЕГРИНЫ, РЕЦЕПТОРЫ, КЛЕТОЧНОЙ АДГЕЗИИ БЕЛОК |
English | Integrin, RGD Receptor, Integrins [Chemical/Ingredient], integrin, integrins, Integrin Receptor, Integrins, Extracellular Matrix, Integrins |
French | Intégrines, Récepteur protéine adhésion cellulaire |
Croatian | INTEGRINI |
Polish | Receptory cząsteczki adhezji komórkowej, Integryny |
German | Integrine |
Italian | Integrine |
Portuguese | Integrinas |
Spanish | Integrinas |
Ontology: Integrin alpha4 (C0252194)
Definition (NCI) | Integrin alpha-4 (1032 aa, ~115 kDa) is encoded by the human ITGA4 gene. This protein is involved in the mediation of both cell-cell and cell-matrix interactions in leukocytes. |
Definition (MSH) | An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits. |
Concepts | Receptor (T192) , Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
MSH | D039441 |
SnomedCT | 103122006 |
LNC | LP20095-3 |
English | CD49d - Cluster of diff ag 49d, Cluster of diff antigen 49d, VLA-4 - V late activ-4 a-chain, Very late activ-4 alpha chain, Integrin alpha4, INTEGRIN ALPHA A 04, ANTIGENS CD 049D, CD 049D ANTIGENS, Integrin alpha4 [Chemical/Ingredient], Integrin Alpha-4, ITGA4, Integrin Alpha-IV, CD49 Antigen-Like Family Member D, VLA-4 Subunit Alpha, Antigen CD49d, CD49d, Antigen, CD49d, CD49d Antigen, Integrin, alpha4, alpha4 Integrin, Antigens, CD49d, CD49d Antigens, CD49d - Cluster of differentiation antigen 49d, Cluster of differentiation antigen 49d, Lymphocyte antigen CD49D, VLA-4 - Very late activation-4 alpha chain, Very late activation-4 alpha chain, Lymphocyte antigen CD49D (substance) |
Swedish | Alfa4-integrin |
Czech | integrin alfa4, antigeny CD49d |
Finnish | Alfa4-integriini |
Russian | INTEGRIN AL'FA-4, ANTIGENY CD49D, АНТИГЕНЫ CD49D, ИНТЕГРИН АЛЬФА-4 |
Japanese | CD49d抗原, インテグリンアルファ4, α4インテグリン, インテグリンα4, 抗原-CD49d |
German | CD 049D ANTIGENE, ANTIGENE CD 049D, INTEGRIN ALPHA A 04, Antigene, CD49d-, CD49d-Antigene, Integrin Alpha4 |
French | Intégrine alpha-4, Antigènes CD49d, CD49d, Antigène CD49d, Intégrine alpha4 |
Polish | Integryna alfa4 |
Spanish | antígeno linfocitario CD49D (sustancia), antígeno linfocitario CD49D, Integrina alfa4, Antígenos CD49d |
Italian | Integrina alfa4 |
Portuguese | Integrina alfa4, Antígenos CD49d |
Ontology: Integrin Receptor Antagonists [MoA] (C2917257)
Concepts | Molecular Function (T044) |
English | Integrin Receptor Antagonists [MoA], Integrin Receptor Antagonists |