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Ontology:
Auranofin
(C0004320)
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Definition (NCI)
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An orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis.
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|
Definition (MSH)
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An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D001310
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| SnomedCT |
391797008, 18002004, 387100001 |
| English |
Auranofin, Gold, (1-thio-beta-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-, auranofin, Auranofin [Chemical/Ingredient], Auranofin - chemical (substance), Auranofin - chemical, Auranofin (product), Auranofin (substance), AURANOFIN |
| Swedish |
Auranofin
|
| Czech |
auranofin
|
| Finnish |
Auranofiini
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| Russian |
AURANOFIN, АУРАНОФИН |
| Polish |
Auranofina
|
| Japanese |
アウラノフィン, オーラノフィン |
| Spanish |
auranofina (producto), auranofina (sustancia), auranofina, Auranofina |
| French |
Auranofine
|
| German |
Auranofin
|
| Italian |
Auranofina
|
| Portuguese |
Auranofina
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Ontology:
Ridaura
(C0699923)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D001310
|
| English |
ridaura, Auranofin Recordati Brand, Auranofin Yamanouchi Brand, Recordati Brand of Auranofin, SmithKline Beecham Brand of Auranofin, Yamanouchi Brand of Auranofin, Ridaura |
