II. Indications

  1. Acute back or Neck Pain interfering with sleep despite Analgesics
    1. Limit to short-course (<14 days)

III. Mechanism

  1. Antispasmodic Skeletal Muscle Relaxant
  2. Centrally acting cyclical Antidepressant with Sedative qualities
    1. Tricyclic amine salt similar to Amitriptyline
  3. Reduces Muscle hyperactivity and somatic motor activity
    1. Mechanism may act at 5-H2 receptors, inhibiting descending serotonergic pathways in the cord

IV. Dosing: Immediate Release

  1. Start: 5 mg orally at bedtime (5 mg is as effective as 10 mg and with less sedation)
  2. Maximum: 10 mg orally three times daily (primarily at bedtime for pain interfering with sleep)

V. Dosing: Extended Release

  1. Start 15 mg orally daily
  2. Maximum: 30 mg orally daily

VII. Efficacy

  1. See Antispasmodic Skeletal Muscle Relaxant
  2. Poor evidence for benefit
    1. More effective than Placebo for first 4 days of Low Back Pain
    2. However, no significant functional or pain benefit at 1 week for Acute Low Back Pain (non-Traumatic, non-radicular)

VIII. Adverse effects

  1. See Antispasmodic Skeletal Muscle Relaxant for precautions
  2. Common: Anticholinergic
    1. Fatigue
    2. Drowsiness
    3. Dry Mouth (Xerostomia)
    4. Urinary Retention
    5. Increased Intraocular Pressure
  3. Rare
    1. Arrhythmia
      1. Reflex Tachycardia
        1. Cyclobenzaprine may block alpha-1 Adrenergic Receptors resulting in vasodilation
      2. QRS Widening
        1. Fast-acting Sodium channel blockade (as with Amitriptyline)
    2. Seizure
      1. GABA Receptor inhibition may lower Seizure threshold
    3. Myocardial Infarction
    4. Serotonin Syndrome
      1. Risk when Cyclobenzaprine is combined with other serotonergic drugs

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Related Studies

Cost: Medications

cyclobenzaprine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CYCLOBENZAPRINE 7.5 MG TABLET Generic $0.66 each