II. Precautions
- See MAO Inhibitors
- Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
- MAO Inhibitors are not first-line agents for Mood Disorders
III. Indications
- Refractory Major Depression
IV. Dosing
- Start: 15 mg orally three times daily
- Target dose: 60-90 mg/day divided two to three times daily
- Maximum: 90 mg/day
- Titrate back down to lowest effective dose as able
V. Mechanism
- See MAO Inhibitor
- Phenelzine is a hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)
VI. Safety
- Unknown safety in pregnancy and Lactation
VII. Adverse Effects
- See MAO Inhibitor
VIII. Drug Interactions
- See MAO Inhibitors
- Hepatic metabolism
IX. Resources
X. References
- (2023) Med Lett Drugs Ther 62(1592): 25-32
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
| phenelzine (on 9/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PHENELZINE SULFATE 15 MG TAB | Generic | $0.57 each |