II. Precautions
- See MAO Inhibitors
- Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
- MAO Inhibitors are not first-line agents for Mood Disorders
III. Indications
- Refractory Major Depression
IV. Dosing
- Start: 15 mg orally three times daily
- Target dose: 60-90 mg/day divided two to three times daily
- Maximum: 90 mg/day
- Titrate back down to lowest effective dose as able
V. Mechanism
- See MAO Inhibitor
- Phenelzine is a hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)
VI. Safety
- Unknown safety in pregnancy and Lactation
VII. Adverse Effects
- See MAO Inhibitor
VIII. Drug Interactions
- See MAO Inhibitors
- Hepatic metabolism
IX. Resources
X. References
- (2023) Med Lett Drugs Ther 62(1592): 25-32
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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phenelzine (on 9/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
PHENELZINE SULFATE 15 MG TAB | Generic | $0.57 each |
Ontology: Phenelzine (C0031392)
Definition (MSH) | One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC. |
Definition (CSP) | monoamine oxidase inhibitor used to treat depression and phobic disorders. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010624 |
SnomedCT | 387528000, 9500005 |
LNC | LP17998-3, MTHU024864 |
English | 2 Phenethylhydrazine, 2-Phenethylhydrazine, Fenelzin, Phenelzine, Phenethylhydrazine, beta Phenylethylhydrazine, beta-Phenylethylhydrazine, phenelzine, Hydrazine, (2-phenylethyl)-, Phenelzine [Chemical/Ingredient], fenelzin, PHENELZINE, MAOI - Phenelzine, Phenelzine (product), Phenelzine (substance) |
Swedish | Fenelzin |
Czech | fenelzin |
Finnish | Feneltsiini |
Russian | FENELZIN, ФЕНЕЛЗИН |
Japanese | フェネルジン |
Italian | beta-Feniletilidrazina, Fenelzina |
Spanish | fenelcina, fenelzina (producto), fenelcina (producto), fenelcina (sustancia), fenelzina (sustancia), fenelzina, Fenelzina, Fenelzin |
Polish | Nardil, Fenelzyna |
French | Phénelzine |
German | Fenelzin, Phenelzin |
Portuguese | Fenelzina |
Ontology: Nardil (C0701388)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010624 |
English | nardil, Nardil, Parke Davis Brand of Phenelzine Sulfate, Pfizer Brand of Phenelzine Sulfate, United Drug Brand of Phenelzine Sulfate |