II. Precautions
- See MAO Inhibitors
- Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
- MAO Inhibitors are not first-line agents for Mood Disorders
III. Indications
- Refractory Major Depression
IV. Background
- Isocarboxazid (Marplan) is no longer manufactured in U.S.
V. Mechanism
- See MAO Inhibitor
- Isocarboxazid is a hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)
VI. Dosing
- Start 10 mg orally twice daily
- May increase the daily dose by 10 mg every 2 to 4 days to 40 mg in the first 1-2 weeks (in divided doses)
- Maximum: 60 mg per day (in divided doses)
VII. Adverse Effects
- See MAO Inhibitor
VIII. Drug Interactions
- See MAO Inhibitors
- Hepatic metabolism
IX. Safety
- Unknown safety in pregnancy and Lactation
X. Resources
- Isocarboxazid (DailyMed)
XI. References
- (2023) Med Lett Drugs Ther 62(1592): 25-32
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia