II. Indications
- Anxiety Disorder
- Anxiety with comorbid Major Depression
- Alcohol Withdrawal
III. Class
- Short acting Benzodiazepine
IV. Pharmacokinetics
- Half Life: 8 to 15 hours
- Metabolism via Glucuronidation to inactive metabolites
V. Dosing: General
-
Anxiety Disorder
- Elderly: 10 mg orally 3 times daily (and may advance to 15 mg orally 3 to 4 times daily)
- Moderate: 10 to 15 mg orally 3 to 4 times daily
- Severe: 15 to 30 mg orally 3 to 4 times daily
- Maximum Daily Dose: 120 mg/day
- Acute Alcohol Withdrawal
- Give 15 to 30 mg orally three to four times daily
VI. Dosing: Equivalent dosing (for Benzodiazepine Withdrawal)
- Valium = Dose x1.0
- Phenobarbital = Dose x3.0
VII. Safety
- Pregnancy Category D
- Avoid in Lactation
- Schedule IV Controlled Substance
VIII. Resources
IX. References
- (2019) Med Lett Drugs Ther 61(1578): 121-6
- (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
oxazepam (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
OXAZEPAM 10 MG CAPSULE | Generic | $0.83 each |
OXAZEPAM 15 MG CAPSULE | Generic | $1.07 each |
OXAZEPAM 30 MG CAPSULE | Generic | $1.24 each |
Ontology: Oxazepam (C0029997)
Definition (NCI) | A synthetic benzodiazepine derivative with anxiolytic and sedative hypnotic properties. Although the mechanism of action has not been fully elucidated, oxazepam appears to enhance gamma-aminobutyric acid (GABA) receptor affinity for GABA, thereby prolonging synaptic actions of GABA. |
Definition (MSH) | A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. |
Definition (CSP) | benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010076 |
SnomedCT | 387455006, 79225003 |
LNC | LP16227-8, MTHU003351 |
English | Oxazepam, oxazepam, 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, Ro 5-6789, Seresta, oxazepam (medication), OXAZEPAM, Oxazepam [Chemical/Ingredient], WY-3498, Oxazepam (product), Oxazepam (substance) |
Swedish | Oxazepam |
Czech | oxazepam |
Finnish | Oksatsepaami |
Russian | OKSAZEPAM, NOZEPAM, TAZEPAM, НОЗЕПАМ, ОКСАЗЕПАМ, ТАЗЕПАМ |
Japanese | オキサゼパム |
Croatian | OKSAZEPAM |
Polish | Oksazepam |
Spanish | oxacepam (producto), oxacepam (sustancia), oxacepam, oxazepam (sustancia), oxazepam, Oxazepam |
French | Oxazepam |
German | Oxazepam |
Italian | Oxazepam |
Portuguese | Oxazepam |
Ontology: Serax (C0702214)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010076 |
English | serax, Serax |