Benzodiazepine Equivalents

Aka: Benzodiazepine Equivalents, Barbiturate Equivalents, Sedative Equivalents

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II. Indications

  1. Benzodiazepine Withdrawal
  2. Barbiturate withdrawal
  3. Sedative withdrawal

III. Preparations: Benzodiazepines Equivalents

  1. Alprazolam (Xanax)
    1. Alprazolam 0.5 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x20
    3. Phenobarbital = Dose x30
  2. Chlordiazepoxide (Librium, Limbitrol)
    1. Chlordiazepoxide 25 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x0.4
    3. Phenobarbital = Dose x1.2
  3. Clonazepam (Klonopin)
    1. Clonazepam 0.5 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x20
    3. Phenobarbital = Dose x7.5
  4. Flurazepam (Dalmane)
    1. Flurazepam 15-30 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x0.33
    3. Phenobarbital = Dose x2.0
  5. Halazepam (Paxipam)
    1. Halazepam 20 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x0.5
    3. Phenobarbital = Dose x0.75
  6. Lorazepam (Ativan)
    1. Lorazepam 1 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x10
    3. Phenobarbital = Dose x15.0
  7. Oxazepam (Serax) 60 mg
    1. Oxazepam 20 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x0.5
    3. Phenobarbital = Dose x3.0
  8. Temazepam (Restoril)
    1. Temazepam 20 mg is equivalent to 10 mg Diazepam
    2. Valium = Dose x0.5
    3. Phenobarbital = Dose x3.0

IV. Preparations: Barbiturate Equivalents

  1. Butabarbital (Butisol)
    1. Valium = Dose x0.1
    2. Phenobarbital = Dose x0.3
  2. Pentobarbital (Nembutal)
    1. Valium = Dose x0.1
    2. Phenobarbital = Dose x0.3
  3. Secobarbital (Seconal)
    1. Valium = Dose x0.1
    2. Phenobarbital = Dose x0.3
  4. Phenobarbital
    1. Valium = Dose x0.33

V. Preparations: Miscellaneous Sedative Equivalents

  1. Glycerol: Meprobamate (Equanil)
    1. Valium= Dose x0.025
    2. Phenobarbital = Dose x0.075
  2. Piperidinedione: Glutethimide (Doriden)
    1. Valium = Dose x0.04
    2. Phenobarbital = Dose x0.12
  3. Quinazoline: Methaqualone
    1. Valium = Dose x0.03
    2. Phenobarbital = Dose x0.1

VI. References

  1. Ashton (2005) Curr Opin Psychiatry 18:249-55 [PubMed]
  2. Tauseef (2012) BJMP 5(1): a501 [PubMed]

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