II. Class

  1. Long acting Benzodiazepine

III. Indications

  1. Anxiety Disorder
  2. Tic Disorder or Tourette's Syndrome
  3. Seizure Disorder
    1. Lennox-Gastaut Syndrome
    2. Akinetic Seizure
    3. Myoclonic Seizure

IV. Dosing

  1. Initial: 0.25 to 0.5 mg PO tid
  2. Titrate: Increase by 0.5 to 1 mg increments q3 days
  3. Maximum Daily Dose: 20 mg

V. Pharmacokinetics

  1. Half Life: 24-48 hours
  2. Rapidly and completely absorbed PO

VI. Equivalent Dosing (for Benzodiazepine Withdrawal)

  1. Valium = Clonazepam Dose x2.5
  2. Phenobarbital = Clonazepam Dose x7.5

VII. Adverse Effects

  1. Sedation
  2. Weight gain
  3. Impaired academic performance
  4. Social anxiety with School Refusal in children
  5. Worsening of attention in children with ADHD
  6. Hypersalivation

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Related Studies

Cost: Medications

clonazepam (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CLONAZEPAM 0.125 MG DIS TAB Generic $0.57 each
CLONAZEPAM 0.125 MG ODT Generic $0.57 each
CLONAZEPAM 0.25 MG ODT Generic $0.52 each
CLONAZEPAM 0.5 MG DIS TABLET Generic $0.54 each
CLONAZEPAM 0.5 MG ODT Generic $0.54 each
CLONAZEPAM 0.5 MG TABLET Generic $0.03 each
CLONAZEPAM 1 MG DIS TABLET Generic $0.62 each
CLONAZEPAM 1 MG ODT Generic $0.62 each
CLONAZEPAM 1 MG TABLET Generic $0.03 each
CLONAZEPAM 2 MG ODT Generic $1.30 each
CLONAZEPAM 2 MG TABLET Generic $0.03 each
klonopin (on 4/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
KLONOPIN 0.5 MG TABLET Generic $0.03 each
KLONOPIN 1 MG TABLET Generic $0.03 each