II. Indications
III. Contraindications
- Severe hepatic Impairment
IV. Dosing
- If doses are missed >72 hours, retitrate up to prior dose (risk of Orthostatic Hypotension)
- Start: 1 mg orally twice daily
- May increase by up to 2 mg orally twice daily slowly (risk of Orthostatic Hypotension with rapid increase)
- Target therapeutic dose: 6 to 12 mg orally twice daily
- Maximum: 24 mg/day
V. Mechanism
- Atypical Antipsychotic Medication
- Dopamine D2 Antagonist
- Serotonin 5HT2 Antagonist
VI. Advantages
- Low risk of Extrapyramidal Side Effects and Akathisia
VII. Adverse Effects
VIII. Drug Interactions
- Metabolized by CYP3A4, CYP2D6
- Decrease dose 50% if taking strong CYP3A4 or CYP2D6 Inhibitors
- Avoid other medication causes of Drug-Induced QTc Prolongation
IX. Resources
X. References
- (2016) Med Lett Drugs Ther 58(1510): 160-5
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 44-5
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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fanapt (on 7/16/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
FANAPT 1 MG TABLET | $27.92 each | |
FANAPT 10 MG TABLET | $54.97 each | |
FANAPT 12 MG TABLET | $55.09 each | |
FANAPT 2 MG TABLET | $28.21 each | |
FANAPT 4 MG TABLET | $27.84 each | |
FANAPT 6 MG TABLET | $34.37 each | |
FANAPT 8 MG TABLET | $34.34 each |
Ontology: iloperidone (C0247194)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C081732 |
SnomedCT | 442910003, 442849001 |
LNC | LP100039-9, MTHU035823 |
English | Ethanone, 1-(4-(3-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)propoxy)-3-methoxyphenyl)-, iloperidone, ILOPERIDONE, Iloperidone, Iloperidone (substance), Iloperidone (product), 4'-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone, antipsychotics iloperidone, Iloperidone (medication) |
Spanish | iloperidona, iloperidona (sustancia), iloperidona (producto) |
Ontology: Fanapt (C2701270)
Concepts | Pharmacologic Substance (T121) |
MSH | C081732 |
English | Fanapt |