II. Indications
-
Parkinsonism
- May be used as monotherapy in early Parkinsonism to delay Levodopa start
- Typically used as adjunctive therapy with Levodopa
- May slow Parkinsonism progression when used in combination with Levodopa
- Reduces "off" time
III. Mechanism
- Irreversible MAO Inhibitor (Type B only, in CNS, Liver, Platelets)
- Inhibits intracerebral Dopamine metabolism
IV. Metabolism
- Rapid oral absorption
- Readily crosses blood brain barrier
- Hepatic metabolism
V. Adverse Effects
- See MAO Inhibitors
- Safety
- Pregnancy Category C
- Unknown safety in Lactation
- Melanoma Risk
VI. Drug Interactions
- See MAO Inhibitors
-
Tyramine Containing Food
- Significant tyramine restriction is not typically needed at typical doses of Type B MAO Inhibitors
- Avoid foods with high tyramine concentrations
-
Hypertensive Crisis risk when combined with other agents
- See MAO Inhibitor
VII. Dosing: Parkinsonism
- Start 0.5 mg orally daily in AM
- Maximum: 1 mg per day
- Maximum 0.5 mg if on CYP1A2 Inhibitor or hepatic Impairment
VIII. Resources
IX. References
- (2021) Med Lett Drugs Ther 63(1618): 25-32
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 46-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| rasagiline (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| RASAGILINE MESYLATE 0.5 MG TAB | Generic | $2.51 each |
| RASAGILINE MESYLATE 1 MG TAB | Generic | $1.47 each |
| azilect (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| AZILECT 0.5 MG TABLET | Generic | $2.51 each |
| AZILECT 1 MG TABLET | Generic | $1.47 each |