II. Precautions

  1. See MAO Inhibitors
  2. Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
  3. MAO Inhibitors are not first-line agents for Mood Disorders

III. Indications

  1. Refractory Major Depression

IV. Dosing: Major Depression

  1. Start: 10 mg orally three times daily
  2. Titrate by 10 mg/day increases every 1 to 3 weeks as needed and as tolerated
  3. Maximum: 60 mg per day (30 mg orally twice daily)

V. Adverse Effects

VI. Drug Interactions

VII. Mechanism

  1. See MAO Inhibitor
  2. Tranylcypromine is a non-hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)

IX. References

  1. (2023) Med Lett Drugs Ther 62(1592): 25-32
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

tranylcypromine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)