II. Precautions
- See MAO Inhibitors
- Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
- MAO Inhibitors are not first-line agents for Mood Disorders
III. Indications
- Refractory Major Depression
IV. Dosing: Major Depression
- Start: 10 mg orally three times daily
- Titrate by 10 mg/day increases every 1 to 3 weeks as needed and as tolerated
- Maximum: 60 mg per day (30 mg orally twice daily)
V. Adverse Effects
- See MAO Inhibitor
VI. Drug Interactions
- See MAO Inhibitors
VII. Mechanism
- See MAO Inhibitor
- Tranylcypromine is a non-hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)
VIII. Resources
- Tranylcypromine (DailyMed)
IX. References
- (2023) Med Lett Drugs Ther 62(1592): 25-32
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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tranylcypromine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
TRANYLCYPROMINE SULF 10 MG TAB | Generic | $0.89 each |
Ontology: Tranylcypromine (C0040778)
Definition (MSH) | A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D014191 |
SnomedCT | 372891006, 89092006 |
LNC | LP14552-1, MTHU001574 |
English | trans-2-Phenylcyclopropylamine, Tranylcypromine, trans 2 Phenylcyclopropylamine, Cyclopropanamine, 2-phenyl-, trans-(+-)-, tranylcypromine, SKF 385, Tranylcypromine [Chemical/Ingredient], TRANYLCYPROMINE, MAOI - Tranylcypromine, Tranylcypromine (product), Tranylcypromine (substance) |
Swedish | Tranylcypromin |
Czech | tranylcypromin |
Finnish | Tranyylisypromiini |
Russian | TRANILTSIPROMIN, ТРАНИЛЦИПРОМИН |
Japanese | トラニルシプロミン |
Polish | Tranylcypromina |
Spanish | tranilcipromina (producto), tranilcipromina (sustancia), tranilcipromina, Tranilcipromina |
French | Tranylcypromine |
German | Tranylcypromin |
Italian | Tranilcipromina |
Portuguese | Tranilcipromina |
Ontology: Parnate (C0701426)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D014191 |
English | parnate, Parnate, Allphar Brand of Tranylcypromine Sulfate, GlaxoSmithKline Brand of Tranylcypromine Sulfate, Goldshield Brand of Tranylcypromine Sulfate, Link Brand of Tranylcypromine Sulfate, SmithKline Brand of Tranylcypromine Sulfate |