Tranylcypromine

Aka: Tranylcypromine, Parnate

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II. Precautions

  1. See MAO Inhibitors
  2. Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
  3. MAO Inhibitors are not first-line agents for Mood Disorders

III. Indications

  1. Refractory Major Depression

IV. Dosing: Major Depression

  1. Start: 10 mg orally three times daily
  2. Titrate by 10 mg/day increases every 1 to 3 weeks as needed and as tolerated
  3. Maximum: 60 mg per day (30 mg orally twice daily)

V. Adverse Effects

  1. See MAO Inhibitor

VI. Drug Interactions

  1. See MAO Inhibitors

VII. Mechanism

  1. See MAO Inhibitor
  2. Tranylcypromine is a non-hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)

VIII. Resources

  1. Tranylcypromine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b72d8187-dfcc-4ea0-b5e9-c0be95b69a27

IX. References

  1. (2023) Med Lett Drugs Ther 62(1592): 25-32
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

tranylcypromine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TRANYLCYPROMINE SULF 10 MG TAB Generic $0.89 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

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