II. Precautions

  1. See MAO Inhibitors
  2. Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
  3. MAO Inhibitors are not first-line agents for Mood Disorders

III. Indications

  1. Refractory Major Depression

IV. Dosing: Major Depression

  1. Start: 10 mg orally three times daily
  2. Titrate by 10 mg/day increases every 1 to 3 weeks as needed and as tolerated
  3. Maximum: 60 mg per day (30 mg orally twice daily)

V. Adverse Effects

VI. Drug Interactions

VII. Mechanism

  1. See MAO Inhibitor
  2. Tranylcypromine is a non-hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)

IX. References

  1. (2023) Med Lett Drugs Ther 62(1592): 25-32
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

tranylcypromine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TRANYLCYPROMINE SULF 10 MG TAB Generic $0.89 each

Ontology: Tranylcypromine (C0040778)

Definition (MSH) A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014191
SnomedCT 372891006, 89092006
LNC LP14552-1, MTHU001574
English trans-2-Phenylcyclopropylamine, Tranylcypromine, trans 2 Phenylcyclopropylamine, Cyclopropanamine, 2-phenyl-, trans-(+-)-, tranylcypromine, SKF 385, Tranylcypromine [Chemical/Ingredient], TRANYLCYPROMINE, MAOI - Tranylcypromine, Tranylcypromine (product), Tranylcypromine (substance)
Swedish Tranylcypromin
Czech tranylcypromin
Finnish Tranyylisypromiini
Russian TRANILTSIPROMIN, ТРАНИЛЦИПРОМИН
Japanese トラニルシプロミン
Polish Tranylcypromina
Spanish tranilcipromina (producto), tranilcipromina (sustancia), tranilcipromina, Tranilcipromina
French Tranylcypromine
German Tranylcypromin
Italian Tranilcipromina
Portuguese Tranilcipromina

Ontology: Parnate (C0701426)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014191
English parnate, Parnate, Allphar Brand of Tranylcypromine Sulfate, GlaxoSmithKline Brand of Tranylcypromine Sulfate, Goldshield Brand of Tranylcypromine Sulfate, Link Brand of Tranylcypromine Sulfate, SmithKline Brand of Tranylcypromine Sulfate