Triazolam

Aka: Triazolam, Halcion

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II. Indication

  1. Insomnia

III. Class

  1. Short Acting Benzodiazepine

IV. Dose

  1. Adult: 0.125 to 0.5 mg PO qhs
  2. Elderly: 0.125 mg PO qhs

V. Pharmacokinetics

  1. Half-Life: 1.5-5.5 hours

VI. Background

  1. Weekly cost: $4.08

VII. Precautions

  1. Reports of Psychosis and Violence
    1. Associated with high dose Halcion (>1 mg)
  2. Likely to be as safe as other Benzodiazepines

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Cost: Medications

triazolam (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
TRIAZOLAM 0.125 MG TABLET Generic $1.28 each
TRIAZOLAM 0.25 MG TABLET Generic $1.27 each
halcion (on 6/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
HALCION 0.25 MG TABLET Generic $1.27 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: Triazolam (C0040879)

Definition (NCI) A triazolobenzodiazepinederivative with sedative-hypnotic property. Triazolam interacts directly with a specific site on the gamma-aminobutyric acid (GABA)-A-chloride-ionophore receptor complex located on the neuronal membrane. Binding causes allosteric modification of the receptor and modulation of its affinity for the inhibitory neurotransmitter GABA. This results in enhancement of synaptic actions of GABA and includes an increase in the frequency of chloride channel openings, increased chloride ion conductance, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability.
Definition (CSP) 8-chloro-6-(2-chlorophenyl)-1-methyl- 1,2,4-triazolobenzodiazepine.
Definition (MSH) A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014229
SnomedCT 111128007, 386984001
LNC LP16298-9, MTHU003366
English Triazolam, 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-, triazolam, clorazolam, triazolam (medication), sedatives triazolam, TRIAZOLAM, Triazolam [Chemical/Ingredient], 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine, Clorazolam, Triazolam (product), Triazolam (substance)
Swedish Triazolam
Czech triazolam
Finnish Triatsolaami
Russian TRIAZOLAM, ТРИАЗОЛАМ
Japanese トリアゾラム
Polish Triazolam
Spanish triazolam (producto), triazolam (sustancia), triazolam, Triazolam
French Triazolam
German Triazolam
Italian Triazolam
Portuguese Triazolam
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Halcion (C0733624)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014229
English Pfizer Brand of Triazolam, Triazolam Pfizer Brand, halcion, Halcion
Derived from the NIH UMLS (Unified Medical Language System)

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