II. Indications

  1. Insomnia
    1. Short-term use only

III. Class

  1. Short Acting Benzodiazepine

IV. Dose

  1. Adult: 0.125 to 0.25 mg orally at bedtime for 7 to 10 days as needed
  2. Elderly: 0.125 mg orally at bedtime for 7 to 10 days as needed
  3. Maximum: 0.5 mg at bedtime (0.25 mg is sufficient in most patients)

V. Pharmacokinetics

  1. Half-Life: 1.5-5.5 hours
  2. Metabolized by CYP3A4 to inactive metabolites

VI. Precautions

  1. Reports of Psychosis and Violence
    1. Associated with high dose Halcion (>1 mg)
  2. Likely to be as safe as other Benzodiazepines

VII. Safety

  1. Pregnancy Category X
  2. Avoid in Lactation
  3. Schedule IV Controlled Substance

IX. References

  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

triazolam (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TRIAZOLAM 0.125 MG TABLET Generic $1.16 each
TRIAZOLAM 0.25 MG TABLET Generic $1.01 each

Ontology: Triazolam (C0040879)

Definition (NCI) A triazolobenzodiazepinederivative with sedative-hypnotic property. Triazolam interacts directly with a specific site on the gamma-aminobutyric acid (GABA)-A-chloride-ionophore receptor complex located on the neuronal membrane. Binding causes allosteric modification of the receptor and modulation of its affinity for the inhibitory neurotransmitter GABA. This results in enhancement of synaptic actions of GABA and includes an increase in the frequency of chloride channel openings, increased chloride ion conductance, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability.
Definition (CSP) 8-chloro-6-(2-chlorophenyl)-1-methyl- 1,2,4-triazolobenzodiazepine.
Definition (MSH) A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014229
SnomedCT 111128007, 386984001
LNC LP16298-9, MTHU003366
English Triazolam, 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-, triazolam, clorazolam, triazolam (medication), sedatives triazolam, TRIAZOLAM, Triazolam [Chemical/Ingredient], 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine, Clorazolam, Triazolam (product), Triazolam (substance)
Swedish Triazolam
Czech triazolam
Finnish Triatsolaami
Russian TRIAZOLAM, ТРИАЗОЛАМ
Japanese トリアゾラム
Polish Triazolam
Spanish triazolam (producto), triazolam (sustancia), triazolam, Triazolam
French Triazolam
German Triazolam
Italian Triazolam
Portuguese Triazolam

Ontology: Halcion (C0733624)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014229
English Pfizer Brand of Triazolam, Triazolam Pfizer Brand, halcion, Halcion