II. Indications

  1. Insomnia
    1. Short-term use only

III. Class

  1. Short Acting Benzodiazepine

IV. Dose

  1. Adult: 0.125 to 0.25 mg orally at bedtime for 7 to 10 days as needed
  2. Elderly: 0.125 mg orally at bedtime for 7 to 10 days as needed
  3. Maximum: 0.5 mg at bedtime (0.25 mg is sufficient in most patients)

V. Pharmacokinetics

  1. Half-Life: 1.5-5.5 hours
  2. Metabolized by CYP3A4 to inactive metabolites

VI. Precautions

  1. Reports of Psychosis and Violence
    1. Associated with high dose Halcion (>1 mg)
  2. Likely to be as safe as other Benzodiazepines

VII. Safety

  1. Pregnancy Category X
  2. Avoid in Lactation
  3. Schedule IV Controlled Substance

IX. References

  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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triazolam (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TRIAZOLAM 0.125 MG TABLET Generic $1.16 each
TRIAZOLAM 0.25 MG TABLET Generic $1.01 each