II. Bone Types
III. Physiology
- Microfractures occur via everyday wear and tear
- Healed by ongoing bone remodeling
- Bone Remodeling
- Bone remodeling occurs in 120 day cycles
- Resorption by Osteoclasts over first 20 days
- Bone formation by Osteoblasts over last 100 days
- Osteoblasts
- Fill in bony cavity with bone matrix
- Triggers for activity
- Parathyroid Hormone
- Thyroxine
- Growth factors
- Interleukins (1, 6, 11)
- Insulin-Like Growth Factors
- Transforming Growth factor-B
- Releases Cytokines to attract Osteoclasts
- Osteoclasts
- Release proteases
- Dissolves bone mineral matrix
- Dissolves Collagen
- Clears away damaged bone
- Releases matrix-bound growth factors
- Chemoattractant for Osteoblasts
- Release proteases
- Bone remodeling occurs in 120 day cycles
- Chemicals involved in bone formation
- Calcitonin
- Inhibits bone resorption
- Inhibits intestinal Calcium, Phosphorus absorption
- Inhibits renal Calcium excretion
- Inhibits calcitriol production in Kidney
- Calcitriol
- Increases intestinal Calcium absorption
- Increases intestinal Phosphorus absorption
- Increases intestinal Magnesium absorption
- Decreases Parathyroid Hormone secretion
- Parathyroid Hormone
- Mobilizes Calcium and Phosphorus from bone
- Increases Calcitriol
- Calcitonin
IV. References
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Related Studies
| Definition (NCI) | Cells which secrete an extracellular matrix into which hydroxyapaetite crystals are deposited to form bone. |
| Definition (MSH) | Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone. |
| Definition (CSP) | bone forming cells which secrete an extracellular matrix, hydroxyapatite crystals are then deposited into the matrix to form bone. |
| Concepts | Cell (T025) |
| MSH | D010006 |
| SnomedCT | 48156001 |
| LNC | LP96511-8 |
| English | Osteoblasts, osteoblast, osteoblasts, cells osteoblasts, cells osteoblast, Osteoblast, Osteoblast (cell) |
| French | Ostéoblaste, Ostéoblastes |
| Swedish | Osteoblaster |
| Czech | osteoblasty |
| Finnish | Osteoblastit |
| Russian | OSTEOBLASTY, ОСТЕОБЛАСТЫ |
| Croatian | OSTEOBLASTI |
| Latvian | Osteoblasti |
| Polish | Komórki kościotwórcze, Osteoblasty |
| Norwegian | Osteoblaster |
| Spanish | osteoblasto (célula), osteoblasto, Osteoblastos |
| German | Osteoblasten |
| Italian | Osteoblasti |
| Dutch | Osteoblast, Osteoblasten |
| Portuguese | Osteoblastos |
Ontology: Osteoclasts (C0029431)
| Definition (NCI) | A large multinuclear cell associated with the absorption and removal of bone. (MeSH) |
| Definition (CSP) | large multinuclear cell associated with the absorption and removal of bone. |
| Definition (MSH) | A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption. |
| Concepts | Cell (T025) |
| MSH | D010010 |
| SnomedCT | 27770000 |
| English | Osteoclasts, osteoclast, osteoclasts, Osteoclast, Osteoclast (cell) |
| French | Ostéoclaste, Ostéoclastes |
| Swedish | Osteoklaster |
| Czech | osteoklasty |
| Finnish | Osteoklastit |
| Russian | OSTEOKLASTY, ODONTOKLASTY, ОДОНТОКЛАСТЫ, ОСТЕОКЛАСТЫ |
| Japanese | 溶骨細胞, 破歯細胞, 破骨細胞, 破骨器 |
| Italian | Osteoclasto, Osteoclasti |
| Croatian | OSTEOKLASTI |
| Polish | Komórki kościogubne, Osteoklasty |
| Norwegian | Osteoklast, Osteoklaster |
| Spanish | osteoclasto (célula), osteoclasto, Osteoclastos |
| German | Osteoklasten |
| Dutch | Osteoclast, Osteoclasten |
| Portuguese | Osteoclastos |
