Osteomalacia

Aka: Osteomalacia

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II. Definition

  1. Defective calcification of bone matrix in adults

III. Pathophysiology

  1. Defective bone calcification after Growth Plates close
  2. Associated with increased Osteoblast activity

IV. Causes

  1. Vitamin D Deficiency
  2. Renal Tubular Acidosis (Vitamin D-Resistant)

V. Symptoms

  1. Anorexia and weight loss
  2. Muscle Weakness
  3. Bone pain

VI. Signs

  1. Skull, spine and Pelvis with deformities
  2. See Vitain D Deficiency

VII. Radiology

  1. Pseudofractures (Looser's Zones)
    1. Radiolucent defects of skull, spine and Pelvis
    2. Transverse lines in bony cortex
  2. Vertebral Fractures

VIII. Management

  1. See Vitamin D Deficiency

IX. References

  1. Drezner in Goldman (2004) Cecil Medicine, p. 1555-62
  2. Lane in Harris (2005) Kelly's Rheumatology, p. 1485-7

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