II. Definition

  1. Defective calcification of bone matrix in adults

III. Pathophysiology

  1. Defective bone calcification after Growth Plates close
  2. Associated with increased Osteoblast activity

V. Symptoms

  1. Anorexia and weight loss
  2. Muscle Weakness
  3. Bone pain

VI. Signs

  1. Skull, spine and Pelvis with deformities
  2. See Vitain D Deficiency

VII. Radiology

  1. Pseudofractures (Looser's Zones)
    1. Radiolucent defects of skull, spine and Pelvis
    2. Transverse lines in bony cortex
  2. Vertebral Fractures

VIII. Management

IX. References

  1. Drezner in Goldman (2004) Cecil Medicine, p. 1555-62
  2. Lane in Harris (2005) Kelly's Rheumatology, p. 1485-7

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