II. Definition

  1. Excess skin and bone proliferation at distal extremity

III. Pathophysiology

  1. Large Platelets accumulate in distal extremities
  2. Fibroblast growth factors released
  3. Results in edema and excess Collagen deposition
  4. Increased bone formation distally also occurs

V. Symptoms

  1. Often asymptomatic
  2. Deep bone pain at distal extremities (usually legs)

VI. Signs

  1. Digital Clubbing
  2. Bone thickening of wrists and ankles

VII. References

  1. Klippel (1997) Primer Rheumatic Diseases, p. 370-1

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