II. Definitions

  1. Tenosynovial Giant Cell Tumor (Nodular Tenosynovitis)
    1. Lobulated benign tumor that encasing finger or toe tendons, and grows slowly over the course of years

III. Findings

  1. Swelling overlying the tendons of the finger (most common) or toes
  2. Second finger is most commonly affected

IV. Labs

  1. Histology
    1. Mononuclear cells
    2. Multinucleated Osteoclast-like giant cells
    3. Hemosiderin-laden Macrophages
    4. Foam cells
    5. Inflammatory infiltrate

V. Imaging

  1. XRay
    1. May demonstrate bony erosions
  2. Ultrasound
    1. Small growth that does not attach to tendon
  3. MRI
    1. T1 with low signal compared with Muscle
    2. T2 with hemosiderin deposition

VI. Management

  1. Surgical resection
    1. Recurrs in up to 15% of cases

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Related Studies

Ontology: Nodular tenosynovitis (C0588125)

Definition (NCI) A well-circumscribed, lobulated tumor, completely or partially covered by a fibrous capsule. It usually arises in the fingers. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. The tumor is slow-growing, usually developing over several years. Clinical presentation includes painless edema of the affected site.
Concepts Neoplastic Process (T191)
SnomedCT 71508003, 95413004
English Nodular tenosynovitis, giant cell tumor tendon sheath, giant cell tendon sheath tumor, cell giant sheath tendon tumor, giant cell tumour tendon sheath, nodular tenosynovitis, cell giant sheath tendon tumour, Nodular tenosynovitis (disorder), Nodular tenosynovitis -RETIRED-, Localized Giant Cell Neoplasm of Tendon Sheath, Localized Giant Cell Neoplasm of Tenosynovium, Localized Giant Cell Neoplasm of the Tenosynovium, Localized Giant Cell Tumor of Tendon Sheath, Localized Giant Cell Tumor of Tenosynovium, Localized Giant Cell Tumor of the Tenosynovium, Localized Tenosynovial Giant Cell Neoplasm, Localized Tenosynovial Giant Cell Tumor, Nodular Tenosynovitis
Spanish tenosinovitis nodular (concepto no activo), tenosinovitis nodular (trastorno), tenosinovitis nodular