II. Interpretation: Normal CSF Protein
- Normal
- Newborn: <150 mg/dl
- Adult: 18 to 58 mg/dl
- CSF Protein is not related to Serum Protein levels
- Low Serum Protein does not cause low CSF Protein
III. Interpretation: Correction of Protein for CSF RBC
IV. Interpretation: Increased CSF Protein
- Diabetes Mellitus
-
Brain Tumor
- Meningioma
- Acoustic Neuroma
- Ependymoma
- Encapsulated Brain Abscess
- Spinal cord tumor
- Multiple Sclerosis
- Acute purulent Meningitis
- Granulomatous Meningitis
- Carcinomatous Meningitis
- Syphilis (Protein may be normal if longstanding)
-
Guillain-Barre Syndrome (Infectious polyneuritis)
- Protein normal during first few days
- Rises after first week
- Cushing's Disease
- Connective Tissue Disease
- Uremia
- Myxedema
- Cerebral Hemorrhage
V. Interpretation: Normal CSF Protein
- Brainstem Glioma
- Viral CNS Infections
- Multiple Sclerosis (Protein may be mildly elevated)
- Ischemic Cerebrovascular Accident
VI. Interpretation: Decreased CSF Protein
- Recent Lumbar Puncture
- Chronic CSF Leakage
- May be normal if age <2 years
- Acute Water Intoxication
VII. References
- Kooiker in Roberts (1998) Procedures in ER, p. 1067-75
- Ravel (1995) Lab Medicine, Mosby, p. 294-9
- Tunkel in Mandell (2000) Infectious Disease, p. 974-8
- Seehusen (2003) Am Fam Physician 68:1103-8 [PubMed]
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Related Studies
| Definition (MSH) | Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221) |
| Concepts | Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D002556 |
| English | Cerebrospinal Fluid Proteins, Fluid Proteins, Cerebrospinal, Proteins, Cerebrospinal Fluid, CSF PROTEINS, PROTEINS CSF, Cerebrospinal Fluid Proteins [Chemical/Ingredient], cerebrospinal fluid proteins, Cerebrospinal fluid proteins |
| Swedish | Likvorproteiner |
| Czech | mozkomíšní mok - proteiny |
| Finnish | Aivo-selkäydinnesteen proteiinit |
| Russian | SPINNOMOZGOVOI ZHIDKOSTI BELKI, СПИННОМОЗГОВОЙ ЖИДКОСТИ БЕЛКИ |
| Spanish | Proteínas del Líquido Cefalorraquídeo |
| French | Protéines du liquide cérébrospinal, Protéines du liquide céphalorachidien, Protéines du liquide céphalo-rachidien, Protéines du liquide cérébro-spinal |
| Croatian | PROTEINI CEREBROSPINALNOG LIKVORA |
| Polish | Białka płynu mózgowo-rdzeniowego |
| Japanese | 脳脊髄液蛋白質, 髄液蛋白質 |
| Portuguese | Proteínas do Líquido Cefalorraquidiano |
| German | Liquorproteine |
| Italian | Proteine del liquido cerebrospinale |
