Family History

Aka: Family History, Pedigree

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II. Epidemiology: Percentage of shared genes among relatives

  1. First Degree Relatives share 50% of genes
    1. Children
    2. Parents
    3. Siblings
  2. Second Degree Relatives share 25% of genes
    1. Aunts and Uncles
    2. Neices and nephews
    3. Grandparents
    4. Half-siblings
  3. Third Degree Relatives share 12.5% of genes
    1. First Cousins
    2. Great Grandparents

III. History: Quick Family History for common diseases

  1. Coronary Artery Disease
  2. Cerebrovascular Accident
  3. Diabetes Mellitus
  4. Breast Cancer
  5. Ovarian Cancer
  6. Colon Cancer

IV. Associated Conditions: Single Gene Diseases

  1. Hemochromatosis (HFE)
  2. Tuberous Sclerosis (TS1, TS2)
  3. Autosomal Dominant Polycystic Kidney Disease (ADPKD1-2)
  4. Hereditary Hemorrhagic Telangiectasia (ENG, ACVRL1)
  5. Idiopathic Pulmonary Hypertension (BMPR2)
  6. Long QT Syndrome
  7. Factor V Leiden or APC Resistance
  8. Alpha-1-Antitrypsin Deficiency (SERPINA)
  9. Glaucoma (MYOC)
  10. Hereditary Pancreatitis (PTSS1)

V. Resources

  1. U.S. Surgeon General's Family History Initiative
    1. http://www.hhs.gov/familyhistory

VI. References

  1. Wattendrof (2005) Am Fam Physician 72(3):441-8 [PubMed]

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