II. Epidemiology
- Prevalence: one in 2000 to 3000
- Diagnosed on average by age 62 years
- Colorectal Cancer present at time of polyposis diagnosis in 25-70%
III. Diagnosis
- Five of more Sessile Serrated Adenomatous Polyps proximal to sigmoid and two or more polyps >1 cm OR
- Any number of Sessile Serrated Adenomatous Polyps proximal to sigmoid and affected first degree relatives OR
- More than 20 Sessile Serrated Adenomatous Polyps of any size throughout the colon
IV. Management: Colorectal Cancer Screening
- Start screening at at age 40 years, or 10 years earlier than youngest relative
- Repeat Colonoscopy every 5 years in those with Family History until polyp is found
- Once serrated polyps are found
- Repeat Colonoscopy annually to clear all polyps
- Colectomy indications
- Colorectal Cancer diagnosis
- Polypectomy cannot control polyps
- Monitoring after colon resection
- Endoscopy of Rectum and residual colon every 6-12 months