II. Epidemiology
- Families predisposed to Atypical Nevi and Melanoma
- Family History of relatives with Melanoma onset at a young age
-
Prevalence: 32000 in United States with Atypical Mole Syndrome
- Accounts for ~5% of moles diagnosed in the United States
- Atypical Nevi in those with Atypical Mole Syndrome carry significant risk of malignant transformation
III. Pathophysiology
- Superficial spreading Melanoma is more common in these families
- Autosomal Dominant inheritance
IV. Diagnosis: Atypical Mole Syndrome
- Malignant Melanoma in at least one first degree or second degree relative
- Large number of melanocytic nevi (typically over 50), variable in size and some with atypia
- Histology demonstrates Atypical Nevi
V. Associated Conditions
- No association with other cancers
VI. References
- Habif (2003) Clinical Dermatology, 4th ed.. Mosby, p. 773-813
- Marghoob (1994) Arch Dermatol 130(8): 993-8 [PubMed]