II. Pathophysiology
- Variant of Dermal Nevus (mole)
- Benign overgrowth of epidermal cells
- Recurrent inflammatory changes resulting in Eczematous or Psoriasis-like changes
- Lesions follow lines of normal Embryologic skin cell migration (blaschko lines)
- Likely result from somatic mutations with genetic mosaicism
III. Epidemiology
- Presents in newborns and young children
- Female gender predominance
- Primarily sporadic but may be genetic
IV. Findings
- Unilateral, scaly, pruritic Plaques or Papules in a linear pattern
- Red, brown or purple lesions (or may be Skin Colored)
V. Management
- No definitive treatment and often refractory to therapy
- Potent Topical Corticosteroids (e.g. Fluocinonide ointment)
- Tacrolimus
- Surgical excision
- Carbon dioxide laser therapy
VI. References
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Related Studies
Concepts | Neoplastic Process (T191) |
MSH | D054000 |
SnomedCT | 729000, 239109005, 399995006 |
English | Dermatitic epidermal naevus, Dermatitic epidermal nevus, ILVEN - Infl lin ver epid naev, Inflam lin verruc epiderm naev, Inflammatory linear verrucous epidermal nevus, Inflammatory Linear Verrucose Epidermal Nevus, Inflammatory Linear Verrucous Epidermal Naevus, Inflammatory linear verrucous epidermal naevus (disorder), ILVEN - Inflammatory linear verrucous epidermal naevus, ILVEN - Inflammatory linear verrucous epidermal nevus, Inflammatory linear verrucous epidermal naevus, Inflammatory linear verrucous epidermal nevus (disorder) |
Norwegian | Inflammatorisk lineært verrukøst epidermalt nevus |
Czech | inflamatorní lineární verukosní epidermální névus, ILVEN |
Spanish | nevo epidérmico inflamatorio verrugoso lineal (trastorno), nevo epidérmico inflamatorio verrugoso lineal |