II. Pathophysiology

  1. Variant of Dermal Nevus (mole)
  2. Benign overgrowth of epidermal cells
  3. Recurrent inflammatory changes resulting in Eczematous or Psoriasis-like changes
  4. Lesions follow lines of normal Embryologic skin cell migration (blaschko lines)
  5. Likely result from somatic mutations with genetic mosaicism

III. Epidemiology

  1. Presents in newborns and young children
  2. Female gender predominance
  3. Primarily sporadic but may be genetic

IV. Findings

  1. Unilateral, scaly, pruritic Plaques or Papules in a linear pattern
  2. Red, brown or purple lesions (or may be Skin Colored)

V. Management

  1. No definitive treatment and often refractory to therapy
  2. Potent Topical Corticosteroids (e.g. Fluocinonide ointment)
  3. Tacrolimus
  4. Surgical excision
  5. Carbon dioxide laser therapy

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Related Studies

Ontology: Inflammatory linear verrucous epidermal nevus (C0473574)

Concepts Neoplastic Process (T191)
MSH D054000
SnomedCT 729000, 239109005, 399995006
English Dermatitic epidermal naevus, Dermatitic epidermal nevus, ILVEN - Infl lin ver epid naev, Inflam lin verruc epiderm naev, Inflammatory linear verrucous epidermal nevus, Inflammatory Linear Verrucose Epidermal Nevus, Inflammatory Linear Verrucous Epidermal Naevus, Inflammatory linear verrucous epidermal naevus (disorder), ILVEN - Inflammatory linear verrucous epidermal naevus, ILVEN - Inflammatory linear verrucous epidermal nevus, Inflammatory linear verrucous epidermal naevus, Inflammatory linear verrucous epidermal nevus (disorder)
Norwegian Inflammatorisk lineært verrukøst epidermalt nevus
Czech inflamatorní lineární verukosní epidermální névus, ILVEN
Spanish nevo epidérmico inflamatorio verrugoso lineal (trastorno), nevo epidérmico inflamatorio verrugoso lineal