II. Pathophysiology

  1. Variant of Dermal Nevus (mole)
  2. Benign overgrowth of epidermal cells
  3. Recurrent inflammatory changes resulting in Eczematous or Psoriasis-like changes
  4. Lesions follow lines of normal Embryologic skin cell migration (blaschko lines)
  5. Likely result from somatic mutations with genetic mosaicism

III. Epidemiology

  1. Presents in newborns and young children
  2. Female gender predominance
  3. Primarily sporadic but may be genetic

IV. Findings

  1. Unilateral, scaly, pruritic Plaques or Papules in a linear pattern
  2. Red, brown or purple lesions (or may be Skin Colored)

V. Management

  1. No definitive treatment and often refractory to therapy
  2. Potent Topical Corticosteroids (e.g. Fluocinonide ointment)
  3. Tacrolimus
  4. Surgical excision
  5. Carbon dioxide laser therapy

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