Dupuytren's Disease

Aka: Dupuytren's Disease, Dupuytren's Contracture, Palmar Fibromatosis

advertisement

II. Definitions

  1. Dupuytren's Contracture (Palmar Fibromatosis)
    1. Idiopathic contractures of the palmar fascia

III. Epidemiology

  1. Onset after age 40 years
  2. More common in men
  3. Highest Incidence regions (northern european descent)
    1. Northern Scotland
    2. Iceland
    3. Norway
    4. Australia

IV. Risk Factors

  1. Diabetes Mellitus (comorbid in 3-33% of diabetes)
    1. Mild cases with slow progression
  2. Increased weekly Alcohol intake
    1. Dupuytren's does not suggest Alcoholism
  3. Tobacco use
  4. Trauma (inconsistent association from studies)
    1. Repetitive occupational Hand Overuse or vibrational exposure
  5. Anticonvulsants (inconsistent association from studies)
  6. Family History
    1. Develops in up to 68% of male relatives of affected patients
    2. Becker (2015) Clin Genet 87(5): 483-7 [PubMed]

V. Pathophysiology

  1. Progressive contractures of the palmar fascia
    1. Proliferating vascular fibrous tissue
    2. Collagen formation
  2. Results in flexion deformity of distal palm and fingers
  3. Unknown underlying etiology
  4. Often bilateral
  5. Autosomal Dominant inheritance, incomplete penetrance

VI. Associated Conditions: Other fibrous contractures

  1. Plantar Fibromatosis
  2. Peyronie's Disease

VII. Signs

  1. Distribution
    1. Fourth finger (most commonly involved)
    2. Fifth finger
    3. Third finger
    4. Second finger (least commonly involved)
  2. Initial: Isolated Nodule at finger forms
    1. Nodule hardens under distal palm
    2. Nodule eventually resorbs
  3. Next: Overlying skin adheres to fascia
    1. Strong fibrous cord develops and extends into finger
    2. Cord contracts and pulls finger into flexion (esp. at MCP and PIP)
    3. Skin puckers on the distal palm
  4. Last: Deformity contracture of fingers
    1. Interference with hand use by contracted fingers
  5. Hueston tabletop test
    1. Patient unable to lay palm flat on tabletop

VIII. Grading

  1. Grade 1: Thickened Nodule/band in palmar aponeurosis
  2. Grade 2: Peritendinous band; limited finger extension
  3. Grade 3: Flexion contracture of finger

IX. Management: Conservative (Grade 1)

  1. Stretching Exercises
  2. Dupuytren's Nodule Corticosteroid Injection

X. Management: Hand surgery

  1. Indications for hand surgery referral
    1. Impaired function
    2. Progressive contracture or disabling deformity
    3. MCP contracture >30 degrees of flexion
    4. PIP contracture of any degree
  2. Surgical correction is ultimately needed in most cases
    1. If corrected early, complete extension is expected
    2. Fasciotomy indications
      1. MCP contracture >40 degrees
      2. PIP contractures >20 degrees
  3. Surgical procedures
    1. Collagenase Injection
    2. Incisional Fasciotomy
    3. Percutaneous Needle Fasciotomy (common in Europe)
      1. In-Office procedure under Local Anesthesia
      2. Foucher (2003) J hand Surg 28:427-31 [PubMed]

XI. Prognosis

  1. Typical course is gradual progressive worsening
  2. Regresses spontaneously in 10% of cases
  3. Worse prognosis factors (faster or severe progression)
    1. Age under 50 years
    2. Tobacco use
    3. Alcohol use
  4. Worse prognosis following surgery
    1. PIP joint contractures
    2. Prognosis worsens the longer a deformity is present

XII. References

  1. Bayat (2006) Ann R Coll Surg Engl 88:3-8 [PubMed]
  2. Pujalte (2024) Am Fam Physician 110(4): 395-401 [PubMed]
  3. Thurston (2003) J Bone Joint Surg Br 85:469-77 [PubMed]
  4. Trojian (2007) Am Fam Physician 76:86-90 [PubMed]

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Dupuytrens Disease." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Studies

Related Topics in Hand Disorders

advertisement