II. Indications for testing

  1. Acute or chronic non-spherocytic Hemolytic Anemia
  2. Asymptomatic children with significant risk factors
  3. Nonphysiologic Neonatal Jaundice with risk factors
  4. Associated risk factors
    1. African, Mediterranean, or Asian ethnicity
    2. Family History of Jaundice, Anemia or Splenomegaly

III. Detection Methods

  1. Quantitative analysis
  2. Rapid fluorescent Spot Test
    1. Detects NADPH generation

IV. False Negatives

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