II. Definition

  1. Bicytopenia: decrease in two of three cell lines
    1. May suggest Pancytopenia in development
  2. Pancytopenia: decrease in all blood cell lines
    1. Anemia
    2. Leukocytopenia
    3. Thrombocytopenia

III. Causes

IV. Signs: Clinical Clues

V. Labs

  1. Complete Blood Count
    1. Pancytopenia consistent with cell counts as below
  2. Peripheral Smear
    1. Macrocytic Anemia
    2. Reticulocytopenia (Reticulocyte Index <1%)
    3. Thrombocytopenia (Platelet Count <20,000/mm3)
    4. Neutropenia
      1. Absolute Neutrophil Count <500/mm3
      2. ANC <200/mm3 suggests very severe disease

VI. Evaluation

  1. Bone Marrow Biopsy: Normal count or hyperplasia
    1. Findings: Blasts, Dysplasia or Fibrosis
    2. Examples (See causes above)
      1. Myelodysplastic Syndrome
      2. Acute Myeloid Leukemia (AML)
      3. Agnogenic myeloid metaplasia
  2. Bone Marrow Biopsy: Fat infiltration (Hypoplasia)
    1. Acquired Aplastic Anemia or
    2. Fanconi's Anemia
      1. Diepoxybutane induced Chromosome breakage or
      2. Mitomycin-C induced Chromosome breakage

VII. References

  1. Lee (1999) Wintrobe's Hematology, Lippincott, p. 1449
  2. Saiki in Friedman (1991) Medical Diagnosis, p. 225

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Related Studies

Ontology: Pancytopenia (C0030312)

Definition (MSHCZE) Současný pokles počtu všech typů krevních buněk (červených a bílých krvinek, krevních destiček). (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (NCI) The inability of the bone marrow to produce hematopoietic elements.
Definition (NCI) A finding of low numbers of red and white blood cells and platelets in the peripheral blood.
Definition (MSH) Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
Concepts Disease or Syndrome (T047)
MSH D010198
ICD9 284.1
ICD10 D61.81
SnomedCT 191250008, 267528007, 312511000009109, 127034005
English Pancytopenia, Pancytopenias, PANCYTOPENIA, Pancytopenia NOS, pancytopenia (diagnosis), pancytopenia, Bone Marrow Failure, Pancytopenia [Disease/Finding], bone marrow failure, pancytopenias, Pancytopenia NOS (disorder), Pancytopenia (finding), Bone marrow failure, Pancytopenia (disorder)
French PANCYTOPENIE, Défaillance de la moelle osseuse, Pancytopénie
Portuguese PANCITOPENIA, Insuficiência da medula óssea, Pancitopenia
Spanish PANCITOPENIA, Insuficiencia de médula ósea, pancitopenia, SAI, pancitopenia, SAI (trastorno), pancitopenia (trastorno), pancitopenia, Pancitopenia
German PANZYTOPENIE, Knochenmarksversagen, Panzytopenie
Dutch beenmergfalen, pancytopenie, Pancytopenie
Italian Insufficienza midollare, Pancitopenia
Japanese 汎血球減少症, 骨髄機能不全, コツズイキノウフゼン, ハンケッキュウゲンショウショウ
Swedish Pancytopeni
Czech pancytopenie, Selhání kostní dřeně, Pancytopenie
Finnish Pansytopenia
Polish Pancytopenia
Hungarian pancytopenia, csontvelő elégtelenség
Norwegian Pancytopeni