II. Definition
- Bicytopenia: decrease in two of three cell lines
- May suggest Pancytopenia in development
- Pancytopenia: decrease in all blood cell lines
- Anemia
- Leukocytopenia
- Thrombocytopenia
III. Causes: General
- Aplastic Anemia
- Vitamin B12 Deficiency
- Folate Deficiency
- Systemic Lupus Erythematosus
- Paroxysmal Nocturnal Hemoglobinuria
- Severe infection
- Brucellosis
- Sarcoidosis
- Pregnancy
- Fanconi's Anemia
- Primary Bone Marrow disorder
- Multiple Myeloma
- Metastatic cancer
- Myelofibrosis
- Osteopetrosis
- Splenic disorder
- Lymphoma
- Gaucher Disease
- Niemann-Pick Disease
- Splenomegaly due to congestion
- Kala-Azar
IV. Causes: By Marrow Findings
- Hypocellular Marrow with Pancytopenia
- Aplastic Anemia
- Fanconi's Anemia
- Copper Deficiency
- Other conditions which may cause hypocellular marrow with Pancytopenia
- Atypical presentations of Leukemia, Lymphoma or Myelodysplastic Syndrome
- Q Fever
- Legionnaire's Disease
- Mycobacterium
- Anorexia Nervosa
- Cellular Marrow with Pancytopenia
- Primary Bone Marrow disorders
- Malignancy
- Systemic Conditions
V. Signs: Clinical Clues
VI. Labs
-
Complete Blood Count
- Pancytopenia consistent with cell counts as below
-
Peripheral Smear
- Macrocytic Anemia
- Reticulocytopenia (Reticulocyte Index <1%)
- Thrombocytopenia (Platelet Count <20,000/mm3)
-
Neutropenia
- Absolute Neutrophil Count <500/mm3
- ANC <200/mm3 suggests very severe disease
VII. Evaluation
-
Bone Marrow Biopsy: Normal count or hyperplasia
- Findings: Blasts, Dysplasia or Fibrosis
- Examples (See causes above)
- Myelodysplastic Syndrome
- Acute Myeloid Leukemia (AML)
- Agnogenic myeloid metaplasia
-
Bone Marrow Biopsy: Fat infiltration (Hypoplasia)
- Acquired Aplastic Anemia or
- Fanconi's Anemia
- Diepoxybutane induced Chromosome breakage or
- Mitomycin-C induced Chromosome breakage
VIII. References
- Lee (1999) Wintrobe's Hematology, Lippincott, p. 1449
- Saiki in Friedman (1991) Medical Diagnosis, p. 225
- Dasgupta (2015) J Lab Physicians 7(2):90-5 +PMID: 26417158 [PubMed]
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Related Studies
Definition (MSHCZE) | Současný pokles počtu všech typů krevních buněk (červených a bílých krvinek, krevních destiček). (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ ) |
Definition (NCI) | The inability of the bone marrow to produce hematopoietic elements. |
Definition (NCI) | A finding of low numbers of red and white blood cells and platelets in the peripheral blood. |
Definition (MSH) | Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets. |
Concepts | Disease or Syndrome (T047) |
MSH | D010198 |
ICD9 | 284.1 |
ICD10 | D61.81 |
SnomedCT | 191250008, 267528007, 312511000009109, 127034005 |
English | Pancytopenia, Pancytopenias, PANCYTOPENIA, Pancytopenia NOS, pancytopenia (diagnosis), pancytopenia, Bone Marrow Failure, Pancytopenia [Disease/Finding], bone marrow failure, pancytopenias, Pancytopenia NOS (disorder), Pancytopenia (finding), Bone marrow failure, Pancytopenia (disorder) |
French | PANCYTOPENIE, Défaillance de la moelle osseuse, Pancytopénie |
Portuguese | PANCITOPENIA, Insuficiência da medula óssea, Pancitopenia |
Spanish | PANCITOPENIA, Insuficiencia de médula ósea, pancitopenia, SAI, pancitopenia, SAI (trastorno), pancitopenia (trastorno), pancitopenia, Pancitopenia |
German | PANZYTOPENIE, Knochenmarksversagen, Panzytopenie |
Dutch | beenmergfalen, pancytopenie, Pancytopenie |
Italian | Insufficienza midollare, Pancitopenia |
Japanese | 汎血球減少症, 骨髄機能不全, コツズイキノウフゼン, ハンケッキュウゲンショウショウ |
Swedish | Pancytopeni |
Czech | pancytopenie, Selhání kostní dřeně, Pancytopenie |
Finnish | Pansytopenia |
Russian | PANTSITOPENIIA, ПАНЦИТОПЕНИЯ |
Polish | Pancytopenia |
Hungarian | pancytopenia, csontvelő elégtelenség |
Norwegian | Pancytopeni |