Neutropenia Causes

Aka: Neutropenia Causes, Agranulocytosis Causes

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II. Causes: Decreased Neutrophil Production

  1. Marrow Infiltration
    1. Leukemia
    2. Myelodysplastic Syndrome
    3. Myelofibrosis (tumor invasion)
    4. Granulomatous infiltration (e.g. Tuberculosis)
  2. Marrow Injury
    1. Radiation
    2. Aplastic Anemia
    3. Paroxysmal Nocturnal Hemoglobinuria
    4. Medications
      1. See Drug-Induced Agranulocytosis
    5. Infection
      1. See Infectious Causes of Neutropenia

III. Causes: Increased Neutrophil Destruction

  1. Severe Sepsis (increased consumption)
  2. Antineutrophil Antibody
  3. Hypersplenism (Splenic trapping)
  4. Felty's Syndrome
  5. Systemic Lupus Erythematosus
  6. Chediak-Higashi Syndrome (rare Autosomal Recessive)
  7. Medications
    1. Phenylbutazone
    2. Phenothiazine

IV. Causes: Lower Clinical Significance

  1. Pseudoneutropenia (based on automated count)
  2. Maturation Defect
    1. Vitamin B12 Deficiency
    2. Folic Acid Deficiency
  3. Margination (distribution)
    1. Bacterial Infection (Endotoxin)
    2. Hemodialysis
    3. Cardiopulmonary bypass

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