II. Physiology
- Amine is synthesized in vivo by enzymatic decarboxylation of Histidine
- Histamine activity is specific to three Histamine receptors
- H1 Receptors (cyclic GMP mediated)
- Bronchoconstriction (e.g. Asthma)
- Adrenal Catecholamine release
- Venoconstriction and increased capillary permeability
- Arteriole and capillary dilation (also H2 receptor mediated)
- Increased cardiac contractility (also H2 receptor mediated)
- Gastrointestinal Muscle Contraction
- H2 Receptors (cyclic AMP mediated)
- Tachycardia
- Increased pepsin and HCl acid secretion from the Stomach
- H3 Receptors
- Inhibits Histamine release from Mast Cells
- H1 Receptors (cyclic GMP mediated)
III. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
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| Definition (CHV) | a chemical substance in the body that produces allergic reactions |
| Definition (CHV) | a chemical substance in the body that produces allergic reactions |
| Definition (NCI_NCI-GLOSS) | A substance that has many effects in the body. It is released from some types of white blood cells during allergic reactions. It causes small blood vessels to dilate (widen) and become leaky, which can cause tissues to swell. It also causes smooth muscles to contract, gastric acid to be made, and the heart rate to increase. Histamine is used in tests for allergies, asthma, and gastric acid secretion. It is a type of neurotransmitter. |
| Definition (MSH) | An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. |
| Definition (CSP) | depressor amine derived by enzymatic decarboxylation of histidine, present in the secretory granules of mast cells; a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. |
| Concepts | Neuroreactive Substance or Biogenic Amine (T124) , Organic Chemical (T109) |
| MSH | D006632 |
| SnomedCT | 54235008 |
| LNC | LP15636-1, MTHU010971 |
| English | Histamine, 1H-Imidazole-4-ethanamine, 5-Imidazoleethylamine, 2-(4-Imidazolyl)ethylamine, 4-(2-Aminoethyl)-1H-imidazole, histamine, Histamine [Chemical/Ingredient], histamines, HISTAMINE, Histamine (substance) |
| Swedish | Histamin |
| Czech | histamin |
| Finnish | Histamiini |
| Russian | GISTAMIN, ГИСТАМИН |
| Japanese | ヒスタミン |
| Croatian | HISTAMIN |
| Polish | Histamina |
| Spanish | histamina (sustancia), histamina, Histamina |
| French | Histamine |
| German | Histamin |
| Italian | Istamina |
| Portuguese | Histamina |
