II. Definitions

  1. Angioedema
    1. Localized, non-Pitting Edema of the deep Dermis and subcutaneous tissue
    2. Asymmetrically affects the face, lips, Tongue, airway, extremities, and in some cases the Abdomen and genitalia

III. Pathophysiology

  1. See Urticaria
  2. Increased vascular permeability
  3. Fluid extravasation into tissues
    1. Edema of the deep Dermis and subcutaneous tissues

IV. Types

  1. Histamine-Mediated Angioedema (mast cell mediated)
    1. See Urticaria
    2. Anaphylaxis (e.g. Angioedema with Urticaria)
    3. Allergic Angioedema without Anaphylaxis
    4. Drug-induced Angioedema
      1. Direct mast cell degranulation
      2. Cause: NSAIDs, Aspirin, Opiates, Vancomycin, Penicillin, Dextran
      3. Anaphylactoid Reaction to Radiocontrast
        1. Immediate reaction to small dose (does not require presensitization)
        2. Contrast with Anaphylaxis which is IgE mediated and requires allergen presensitization
    5. Idiopathic histaminergic Angioedema
  2. Bradykinin-Mediated Angioedema
    1. Angiotensin Converting Enzyme Inhibitor (ACE Inhibitor) use
      1. Reaction may occur months to years after ACE Inhibitor initiation
      2. ACE-Inhibitor induced Angioedema is not an Allergic Reaction (unlike typical Angioedema)
        1. Related to bradykinin accumulation
        2. Does not respond to typical Angioedema management (e.g. Corticosteroids, Antihistamines)
      3. More common in african american patients by factor of 2-4 fold
      4. Reaction can occur months to years after starting an ACE Inhibitor
      5. Treatment is withdrawal of medication and supportive care
        1. ACE-Inhibitor Angioedema will recur with ARB agents in 8% of patients
        2. Reactions may be severe and life threatening with complete airway closure
    2. Hereditary Angioedema (HAE)
      1. Presents with recurrent facial swelling and Colicky Abdominal Pain
      2. Autosomal Dominant Abnormal C1 Esterase Inhibitor
        1. Allows for increased plasma kallikrein activity
        2. Results in increased bradykinin levels

V. Symptoms

  1. Edema
    1. Facial, Tongue or lip swelling
    2. Abdomen or genitalia swelling
    3. Extremity swelling
  2. Airway edema related symptoms
    1. Dysarthria (related to Tongue swelling)
    2. Stridor or Wheezing
    3. Dyspnea
  3. Rash
    1. See signs below
    2. Pruritus and Urticaria (if histamine-mediated)
  4. Gastrointestinal symptoms (if edema affects intestinal tract)
    1. Nausea
    2. Vomiting
    3. Diarrhea
    4. Abdominal Pain

VI. Signs

  1. May be associated with Anaphylaxis
  2. May occur with Urticaria
  3. Nonpitting, subcutaneous swelling
    1. Well demarcated
    2. Distribution
      1. Face
      2. Hands
      3. Buttocks
      4. Genitalia
      5. Abdomen
      6. Laryngeal Angioedema (more common in Bradykinin-Mediated Angioedema)
  4. Skin changes
    1. Pruritic Urticaria
      1. Associated with histamine mediated Angioedema
      2. May be associated with Anaphylaxis
    2. Non-pruritic, Firm Papules
      1. Associated with bradykinin mediated Angioedema
  5. Associated findings
    1. Wheezing or Stridor
    2. Fever
    3. Lymphadenopathy
    4. Hypotension
      1. May occur with either histamine-mediated or Bradykinin-Mediated Angioedema
    5. Abdominal tenderness with tense Abdomen and guarding (from bowel wall edema)
      1. Associated with bradykinin mediated Angioedema

VII. Management: Acute Angioedema

  1. ABC Management
    1. Evaluate on presentation and repeatedly for impending airway compromise
    2. Evaluate the lips, Tongue, Soft Palate and posterior pharynx
    3. Evaluate for Stridor, Hoarseness, Drooling or respiratory distress (glottic or supraglottic swelling)
      1. Warrants direct visualization of Larynx (e.g. fiberoptic Nasolaryngoscopy)
      2. Prepare for secure airway (Endotracheal Intubation) and optimize ETT first pass success
        1. Consider Awake Nasotracheal Intubation
        2. Consider Ketamine induction with Video Laryngoscopy
      3. Prepare for surgical airway (emergency Cricothyrotomy)
      4. Supraglottic Devices, Nasal Airways and NIPPV are not viable alternatives in laryngeal Angioedema
  2. Specific Management (choose one of the following mechanisms, and follow pathways below)
    1. Histamine-Mediated Angioedema
      1. Typically triggered by food or other allergen
      2. Often accompanied by Urticaria
      3. Treated as Anaphylaxis (Epinephrine, Antihistamines or Corticosteroids)
    2. Bradykinin-Mediated Angioedema Specific Management
      1. Urticaria and Pruritus is typically absent (although firm Papules may be present)
      2. More often associated with laryngeal edema
      3. Does not typically respond to Epinephrine, Antihistamines or Corticosteroids

VIII. Management: Histamine Mediated Angioedema

  1. See Allergic Reaction and Anaphylaxis
  2. See Urticaria
  3. Medications (ineffective in Bradykinin-Mediated Angioedema)
    1. See Anaphylaxis for dosing regimens and details
    2. Epinephrine
    3. Fluid Resuscitation (if hypotensive)
    4. Bronchodilator Nebulizer Treatment, e.g. Duoneb (if respiratory distress or Wheezing)
    5. Antihistamines (Diphenhydramine and consider H2 Blockers)
    6. Corticosteroids

IX. Management: Bradykinin-Mediated Angioedema Specific Management

  1. Indications
    1. Severe, airway compromising Hereditary Angioedema
    2. ACE Inhibitor Angioedema (off label use, and mixed evidence)
  2. Medications
    1. C1 Human Esterase Inhibitor (e.g. Berinert, Cinryze )
      1. Indicated in acute Hereditary Angioedema affecting the face, Larynx or Abdomen in any age
      2. Berinert: 20 IU/kg IV for 1 dose ($3000 per dose)
      3. Cinryze is approved for prophylaxis of Hereditary Angioedema
        1. Dose: 1000 units IV every 3-4 days
    2. Selective Bradykinin B2 inhibitor (Icatibant)
      1. Primary Indication: Hereditary Angioedema
      2. Effective in one RCT for ACE Inhibitor Angioedema (symptoms resolved 19 hours faster)
        1. Dose: 30 mg SQ (and may repeat in 6 hours if inadequate effect, $10,000/dose)
        2. Bas (2015) N Engl J Med 372(5):418-25 +PMID:25629740 [PubMed]
      3. Icatibant did not show benefit in ACE Inhibitor Angioedema subsequent Phase III trial
        1. Swaminathan and Wilkerson in Herbert (2016) EM:Rap 16(3): 3-4
    3. Recombinant Plasma Kallikrein Inhibitor (Ecallantide)
      1. Indicated in Hereditary Angioedema (age 16 years old or older)
      2. Dose: 30 mg SQ once (and may be repeated in 24 hours)
      3. Risk of Anaphylactic or anaphylactoid reaction (3%)
    4. Fresh Frozen Plasma (FFP)
      1. Indicated if the above agents (C1 and B2) are unavailable in severe Hereditary Angioedema
        1. May also consider in ACE-Inhibitor induced Angioedema
      2. Theoretical risk of exacerbating Angioedema (due to complement in FFP)
      3. Inconsistent benefit in Bradykinin-Mediated Angioedema
      4. Hassen (2013) J Emerg Med 44(4):764-72 +PMID:23114109 [PubMed]
    5. Other medications
      1. Corticosteroids may be considered
      2. Epinephrine is unlikely to be beneficial
      3. Antihistamines are not indicated

X. Management: Disposition

  1. General approach
    1. Minimal observation duration: 4-6 hours after maximal swelling has occurred
    2. Monitor on continuous cardiac monitor and Oxygen Saturation
    3. Histamine-Mediated Angioedema discharge medications (see Anaphylaxis)
      1. Short course (e.g. 3 days) of Corticosteroids, Antihistamines
      2. Epinephrine Autoinjector
    4. Bradykinin-Mediated Angioedema
      1. Discontinue ACE Inhibitor and Angiotensin Receptor Blockers
      2. Follow-up allergist
  2. Face and lip swelling
    1. Observe in Emergency Department and discharge home
  3. Anterior Tongue and oral cavity swelling
    1. Obtain fiberoptic examination of upper airway
    2. Observe in Emergency Department or on inpatient ward
  4. Posterior Tongue and floor of mouth swelling
    1. Consider intubation
    2. Observe on inpatient ward or intensive care unit
  5. Laryngeal and supraglottic swelling
    1. Strongly consider intubation
    2. Intensive care admission

XI. References

  1. Callahan and Gingold (2019) Crit Dec Emerg Med 33(4): 3-11
  2. Frank in Goldman (2000) Cecil Medicine, p. 1440-5
  3. Kaplan in Middleton (1998) Allergy, p. 1104-18
  4. Habif (1996) Clinical Dermatology, p. 122-47
  5. Cicardi (2014) Intern Emerg Med 9(1):85-92 +PMID: 24002787 [PubMed]
  6. Greaves (2000) J Allergy Clin Immunol 105:664-72 [PubMed]
  7. Muller (2004) Am Fam Physician 69(5):1123-8 [PubMed]

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Related Studies

Ontology: Angioedema (C0002994)

Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (CHV) Recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes
Definition (NCI) Rapid swelling of the deep layers of the skin due to transient vascular leakage of serous fluid.(NICHD)
Definition (MSH) Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.
Concepts Pathologic Function (T046)
MSH D000799
ICD10 T78.3
SnomedCT 269433002, 157756002, 400075008, 41291007, 82966003
English Angioedemas, Angioneurotic Edemas, Edemas, Angioneurotic, Giant Urticarias, Quincke Edema, Quincke's Edema, Quinckes Edema, Urticaria, Giant, Urticarias, Giant, Edema, Quincke's, ANGIOEDEMA, ANGIONEUROTIC EDEMA, ANGIONEUROTIC OEDEMA, Edema, Angioneurotic, GIANT HIVES, GIANT URTICARIA, Giant Urticaria, QUINCKE'S EDEMA, QUINCKE'S OEDEMA, Urticaria giant, Hives giant, Oedema angioneurotic, Giant hives, Edema angioneurotic, Edema Quincke's, Angio-edema, Oedema Quincke's, Angio-edema-urticaria, Urticaria-angio-edema, Angioneurotic Edema, Angioedema, angioedema (diagnosis), angioedema, Angioedema and urticaria, Angioedema [Disease/Finding], angioedema urticaria, Oedema;angioneurotic, quincke edema, quincke's edema, urticaria angioedema, angio edema, angio oedema urticaria, angio oedema, giant hives, quincke's disease, Giant urticaria, Angioneurotic edema, Quincke's edema, Angioneurotic oedema, Quincke's oedema, Quincke's disease, Angio-oedema, Angio-oedema-urticaria, Urticaria-angio-oedema, Giant urticaria (disorder), Angioedema (disorder), Angioedema-urticaria, Urticaria-angioedema, giant urticaria, circumscribed; edema, Quincke; edema, Quincke, edema; Quincke, edema; angioneurotic, edema; circumscribed, giant; urticaria, angioneurotic; edema, urticaria; giant, Angioedema, NOS, Angioneurotic edema, NOS, angioneurotic edema, angioneurotic oedema, Edema;angioneurotic
French URTICAIRE GEANTE, Angio-oedème, Urticaires géantes, Oedème de Qincke, Oedème angionévrotique, Angioedème, Oedème de Quincke, ERUPTION ALLERGIQUE GEANTE, OEDEME ANGIONEUROTIQUE, OEDEME ANGIONEVROTIQUE, OEDEME DE QUINCKE, Angioedèmes, Angioedèmes et urticaires, Urticaire géante, Oedème angioneurotique
Portuguese EDEMA ANGIONEUROTICO, ANGIOEDEMA, EDEMA DE QUINCKE, URTICARIA GIGANTE, Angiedema, Edema angioneurótico, Urticária gigante, Edema angioneurõtico, Angioedema, Angiodemas, Angioedema e urticária, Edema de Quincke, Urticária Gigante
Spanish EDEMA ANGIONEUROTICO, ANGIOEDEMA, EDEMA DE QUINCKE, URTICARIA GIGANTE, Edema angioneurótico, Urticaria gigante, Angioedema, angioedema (trastorno), angioedema, edema angioneurótico, edema de Quincke, urticaria gigante (trastorno), urticaria gigante, Angioedema y urticaria, Angioedemas, Edema de Quincke, Urticaria Gigante
Italian Angioedema ed orticaria, Angioedemi, Edema angioneurotico, Edema di Quincke, Orticaria gigante, Angioedema
Japanese 血管浮腫および蕁麻疹, ケッカンフシュオヨビジンマシン, ケッカンシンケイセイフシュ, クインケフシュ, キョダイジンマシン, ケッカンフシュ, Quincke浮腫, 血管神経性浮腫, クインケ浮腫, 巨大じんま疹, 巨大浮腫, 巨大蕁麻疹, 皮膚浮腫, 脈管神経性水腫, 脈管神経性浮腫, 脈管運動神経性水腫, 脈管運動神経性浮腫, 血管浮腫, 血管神経性水腫, 血管運動神経性水腫, 血管運動神経性浮腫, 遊走性水腫, じんましん-巨大, 巨大じんましん, 蕁麻疹-巨大, 血管性浮腫
Dutch netelroos (galbulten), oedeem, Quincke, oedeem angioneurotisch, angio-oedeem, angioneurotisch oedeem, giga urticaria, reuzenurticaria, Quincke; oedeem, angioneurotisch; oedeem, circumscript; oedeem, oedeem; Quincke, oedeem; angioneurotisch, oedeem; circumscript, reuzen; urticaria, urticaria; reuzen, angio-oedeem en urticaria, angio-oedemen, Angio-oedeem, Angioneurotisch oedeem, Oedeem, angioneurotisch, Quincke-oedeem, Urticaria, reuzen-
German Quincke-Oedem, Riesenurtikaria, angioneurotisches Oedem, Oedem angioneurotisch, Oedem Quinke, Quaddeln riesig, Angiooedem, Riesenquaddeln, ANGIOOEDEM, Angioneurotisches Oedem, OEDEM ANGIONEUROTISCH, QUINCKE OEDEM, URTICARIA GIGANTEA, URTIKARIA GIGANTEA, Angiooedem und Urtikaria, Angiooedeme, Urticaria gigantea, Angioneurotisches Ödem, Angioödem, Quincke-Ödem
Finnish Angioedeema
Russian KRAPIVNITSA GIGANTSKAIA, ANGIONEVROTICHESKII OTEK, АНГИОЭДЕМА, ANGIOEDEMA, АНГИОНЕВРОТИЧЕСКИЙ ОТЕК, KVINKE OTEK, КВИНКЕ ОТЕК, КРАПИВНИЦА ГИГАНТСКАЯ
Swedish Angioödem
Czech Angioedémy, Kopřivka tvořená rozsáhlými kopřivkovými pupeny, Rozsáhlá kopřivka, Velkopupenová kopřivka, Quinckeho edém, Angioneurotický edém, Angioedém, Angioedém a kopřivka, Kopřivka tvořená rozsáhlými pomfy, angioedém, angioneurotický edém
Korean 혈관신경성 부종
Polish Obrzęk naczynioruchowy, Obrzęk naczyniowo-nerwowy, Obrzęk Quinckego
Hungarian Angio-oedemák, Quincke oedema, Angio-oedema és urticaria, Angio-oedema, Quincke-vizenyő, Óriás urticaria, Quincke-oedema, Angioneurotikus oedema, Oedema, angioneurotica, Óriás csalánkiütés, Urticaria óriás, angioneurotikus oedema, Angiooedema, ér eredetű vizenyő, Oedema angioneurotica, Csalánkiütés, óriás, Quincke-edema
Norwegian Quinckes ødem, Angionevrotisk ødem, Angioødem, Urticaria gigantea

Ontology: Angioedemas, Hereditary (C0019243)

Definition (MSH) Inherited disorders that are characterized by subcutaneous and submucosal EDEMA in the upper RESPIRATORY TRACT and GASTROINTESTINAL TRACT.
Definition (NCI) Autosomal dominant inherited disorder characterized by abnormalities of C1 inhibitor. Patients present with swelling of the skin, subcutaneous tissues, and mucosa sites.
Definition (SNOMEDCT_US) Inherited form of angioedema caused by decreased levels or function of C1 inhibitor or other mechanisms leading to increased levels of bradykinin
Definition (CSP) recurring attacks of transient edema suddenly appearing in areas of the skin or mucous membranes and occasionally of the viscera, often associated with dermatographism, urticaria, erythema, and purpura.
Concepts Disease or Syndrome (T047)
MSH D054179
SnomedCT 82966003
English hereditary angioneurotic edema, C1 esterase inhibitor defic, Hereditary angio-edema, HANE - Her angioneurot edema, HANE - Her angioneurot oedema, ANGIONEUROTIC EDEMA, HEREDITARY, C1 ESTERASE INHIBITOR, DEFICIENCY OF, HANE, HAE - Hereditary angio-edema, Hereditary Angioneurotic Edema, Edema, Hereditary Angioneurotic, Angioneurotic Edemas, Hereditary, Hereditary Angioneurotic Edemas, Hereditary Angioedema, Edemas, Hereditary Angioneurotic, complement esterase deficiency, HAE, C1 inhibitor deficiency ('hereditary angioedema'), Angioedema, Hereditary, Hereditary Angioedemas, Angioedemas, Hereditary, Angioedemas, Hereditary [Disease/Finding], angioedema hereditary, hereditary angio-edema, hereditary angio-oedema, angio edema hereditary, c1 inhibitor deficiency, c1 esterase inhibitor deficiency, hereditary angioedema, hane, Angioneurotic Edema, Hereditary, C1 inhibitor deficiency, c1 inhibitor deficiency (diagnosis), Hereditary angioedema (diagnosis), C1 Esterase Inhibitor Deficiency, C1 Inhibitor Deficiency, Hereditary angioneurotic edema (disorder), Hereditary angioneurotic edema, Hereditary angio-oedema, Hereditary angioedema (disorder), Hereditary angioneurotic oedema, Hereditary angioedema, C-1 esterase inhibitor deficiency, C1 esterase inhibitor deficiency, HAE - Hereditary angioedema, HANE - Hereditary angioneurotic edema, HANE - Hereditary angioneurotic oedema, HAE - Hereditary angio-oedema, Hereditary Quincke's edema, Hereditary Quincke's oedema, deficiency; C1 esterase inhibitor, Quincke; edema, hereditary, Quincke; hereditary, Bannister; hereditary, edema; Quincke, hereditary, edema; angioneurotic, hereditary, hereditary; Bannister, hereditary; Quincke, hereditary; angioedema, hereditary; angioneurotic edema, C1 esterase inhibitor; deficiency, angioedema; hereditary, angioneurotic; edema, hereditary
Italian Angioedema ereditario, Deficit di inibitore della C1 esterasi, Angioedemi ereditari
Dutch C1-esteraseremmerdeficiëntie, Bannister; hereditair, C1-esteraseremmer; deficiëntie, Quincke; hereditair, Quincke; oedeem, hereditair, angio-oedeem; hereditair, angioneurotisch; oedeem, hereditair, deficiëntie; C1-esteraseremmer, hereditair; Bannister, hereditair; Quincke, hereditair; angio-oedeem, hereditair; angioneurotisch oedeem, oedeem; Quincke, hereditair, oedeem; angioneurotisch, hereditair, angio-oedeem, erfelijk
French Carence en inhibiteurs de la C1 estérase, AOH (Angio-Oedème Héréditaire), OANH, Oedèmes angio-neurotiques héréditaires, Oedèmes angioneurotiques héréditaires, Angioedèmes héréditaires, Angio-oedèmes héréditaires, Angioedème héréditaire
German C1-Esterase-Inhibitor-Mangel, Hereditäres Angioödem, Angioödem, Hereditäres, Hereditäres angioneurotisches Ödem, Angiooedem hereditaer
Portuguese Carência de inibidor da esterase C1, Angioedema Hereditário, Angioedemas Hereditários, Angioedema hereditário
Spanish Deficiencia del inhibidor de la C1 esterasa, Angioedemas Hereditarios, Angioedema Hereditario, angioedema hereditario, deficiencia del inhibidor de la C1 estearasa, edema angioneurótico hereditario (trastorno), edema angioneurótico hereditario, edema de Quincke hereditario, Angioedema hereditario
Japanese C1エステラーゼインヒビター欠損, C1エステラーゼインヒビターケッソン, イデンセイケッカンフシュ, 遺伝性血管神経浮腫, 遺伝性血管神経性浮腫, 遺伝性血管性浮腫, 遺伝性血管神経浮腫症, 血管性浮腫-遺伝性, 遺伝性血管浮腫, 遺伝性血管神経性水腫, 血管神経性浮腫-遺伝性
Finnish Perinnöllinen angioedeema
Russian ANGIOEDEMA NASLEDSTVENNAIA, АНГИОЭДЕМЫ НАСЛЕДСТВЕННЫЕ, ANGIOEDEMY NASLEDSTVENNYE, АНГИОЭДЕМА НАСЛЕДСТВЕННАЯ
Czech Hereditární angioedém, Deficit inhibitoru C1 esterázy, angioedém hereditární, dědičný angioneurotický edém, angioedém dědičný, angioedémy dědičné, angioedémy hereditární
Swedish Angioödem, ärftlig
Polish Obrzęki naczynioruchowe dziedziczne, Obrzęk naczynionerwowy dziedziczny, Dziedziczny obrzęk angioneurotyczny, Obrzęk angioneurotyczny dziedziczny, Dziedziczny obrzęk naczynioruchowy
Hungarian C1 esterase inhibitor hiány, Öröklött angio-oedema
Norwegian Arvelig angioødem, Angioødem, hereditært, Arvelig elveblest, Hereditært angioødem

Ontology: Drug-aggravated angioedema-urticaria (C0413239)

Concepts Disease or Syndrome (T047)
SnomedCT 241958006
English Drug-ind angio-edema-urticar, Drug-induced angio-edema-urticaria, Drug-ind angio-oedema-urticar, Drug-aggr angio-edema-urticar, Drug-aggr angio-oedema-urticar, Drug-aggravated angio-edema-urticaria, Pharmacol-aggravated urticaria, Drug-induced angio-oedema-urticaria, Drug-aggravated angio-oedema-urticaria, Pharmacological-aggravated urticaria, Drug-aggravated angioedema-urticaria (disorder), Drug-induced angioedema-urticaria, Drug-aggravated angioedema-urticaria
Spanish urticaria angioedematosa agravada por fármacos (trastorno), urticaria angioedematosa agravada por fármacos

Ontology: Allergic angioedema (C0920175)

Concepts Pathologic Function (T046)
ICD10 T78.3
SnomedCT 402387002
Dutch allergisch angio-oedeem
French Angioedème allergique
German allergisches Angiooedem
Italian Angioedema allergico
Portuguese Angiedema alérgico
Spanish Angioedema por alergia, angioedema alérgico (trastorno), angioedema alérgico
Japanese アレルギー性血管浮腫, アレルギーセイケッカンフシュ
Czech Alergický angioedém
Hungarian Allergiás angio-oedema
English Allergic angioedema, Allergic angio-oedema, Allergic angioedema (disorder)

Ontology: ACE inhibitor-aggravated angioedema (C1268945)

Concepts Injury or Poisoning (T037)
SnomedCT 371627004
English ACE inhibitor-aggravated angioedema (disorder), Angiotensin converting enzyme (ACE) inhibitor-aggravated angio-oedema, Angiotensin converting enzyme (ACE) inhibitor-aggravated angioedema, ACE inhibitor-aggravated angio-edema, Angiotensin converting enzyme inhibitor-aggravated angioedema, Angiotensin converting enzyme inhibitor-aggravated angioedema (disorder), Angiotensin converting enzyme (ACE) inhibitor-aggravated angioedema (disorder), angioedema angiotensin converting enzyme inhibitor-aggravated, Angiotensin converting enzyme inhibitor-aggravated angioedema (diagnosis), ACE inhibitor-aggravated angio-oedema, ACE inhibitor-induced angio-oedema, ACE inhibitor-aggravated angioedema, ACE inhibitor-induced angioedema, ACE inhibitor-induced angio-edema
Spanish angioedema agravado por inhibidor de la enzima convertidora de angiotensina, angioedema agravado por IECA, angioedema agravado por inhibidor de la enzima convertidora de angiotensina (trastorno), angioedema agravado por inhibidor de la ECA, angioedema inducido por inhibidor de la enzima convertidora de angiotensina (trastorno), angioedema inducido por inhibidor de la ECA, angioedema inducido por inhibidor de la enzima convertidora de angiotensina, edema angioneurótico agravado por inhibidor de la enzima convertidora de angiotensina

Ontology: Angioedema due to disorder of kinin metabolism (C3839758)

Concepts Pathologic Function (T046)
SnomedCT 703795004
English Angioedema due to disorder of kinin metabolism, Angioedema due to disorder of kinin metabolism (disorder), Angio-oedema due to disorder of kinin metabolism