Erythema Multiforme Differential Diagnosis

Aka: Erythema Multiforme Differential Diagnosis

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II. Differential Diagnosis: Severe illnesses with Erythema Multiforme type lesions

  1. See Life-Threatening Drug-Induced Rashes
  2. Erythema Multiforme Major (Stevens Johnson Syndrome) include mucous membrane involvement
  3. Toxic Epidermal Necrolysis

III. Differential Diagnosis: General Skin Lesions

  1. Chronic Urticaria
    1. Urticarial lesions persist <24 hours, then migrate
    2. Contrast with Erythema Multiforme lesions remain fixed for at least 7 days
  2. Serum Sickness
  3. Figurate erythema
  4. Toxic erythema
    1. Viral Exanthem
    2. Fixed Drug Eruption
  5. Graft Versus Host Disease
  6. Necrotizing Vasculitis
  7. Systemic Lupus Erythematosus
  8. Erythema Nodosum
  9. Pityriasis Rosea
  10. Polymorphous Light Eruption

IV. Differential Diagnosis: Vesiculobullous lesions

  1. Bullous Pemphigoid
  2. Pemphigus Vulgaris
  3. Impetigo
  4. Toxic Epidermal Necrolysis
  5. Dermatitis Herpetiformis
  6. Behcet's Syndrome
  7. Reiter's Syndrome

V. Differential Diagnosis: Mucocutaneous lesions (Erythema Multiforme Major)

  1. See Oral Ulcer
  2. Cicatricial Pemphigoid
  3. Pemphigus Vulgaris
  4. Lichen Planus
  5. Aphthous Ulcer
  6. Acute Herpetic Mucositis

VI. References

  1. Long (2016) Crit Dec Emerg Med 30(7):3-10
  2. Lamoreux (2006) Am Fam Physician 74:1883-8 [PubMed]
  3. Leaute-Labreze (2000) Arch Dis Child 83:347-52 [PubMed]
  4. Trayes (2019) Am Fam Physician 100(2): 82-8 [PubMed]
  5. Williams (2005) Dent Clin North Am 49:67-76 [PubMed]

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