II. Differential Diagnosis: Severe illnesses with Erythema Multiforme type lesions

III. Differential Diagnosis: General Skin Lesions

  1. Chronic Urticaria
    1. Urticarial lesions persist <24 hours, then migrate
    2. Contrast with Erythema Multiforme lesions remain fixed for at least 7 days
  2. Serum Sickness
  3. Figurate erythema
  4. Toxic erythema
    1. Viral Exanthem
    2. Fixed Drug Eruption
  5. Graft Versus Host Disease
  6. Necrotizing Vasculitis
  7. Systemic Lupus Erythematosus
  8. Erythema Nodosum
  9. Pityriasis Rosea
  10. Polymorphous light eruption

V. Differential Diagnosis: Mucocutaneous lesions (Erythema Multiforme Major)

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