Dimenhydrinate

Aka: Dimenhydrinate, Dramamine Original Formulation

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II. Indications

  1. Vertigo
  2. Nausea and Vomiting
  3. Hyperemesis Gravidarum

III. Contraindications

  1. Concurrent MAO Inhibitor use
  2. Caution in Narrow Angle Glaucoma
  3. Caution in Benign Prostatic Hyperplasia with obstruction

IV. Mechanism

  1. First-generation histamine Antagonist (Sedating Antihistamine, Ethanolamine)
    1. Competitively blocks H1 Receptors at gastrointestinal Smooth Muscle as well as at Bronchial Smooth Muscle and capillaries
  2. Effects
    1. Inhibits Histamine-induced bronchoconstriction
    2. Inhibits Histamine induced vasodilation and capillary permeability
    3. Inhibits gastrointestinal Smooth Muscle spasm

V. Dosing: Nausea or Vomiting

  1. Adults (and children age > 12 years)
    1. Take 50 to 100 mg PO/IM/IV every 4 to 6 hours as needed (max: 400 mg/day orally, 600 mg/day IV/IM)
  2. Children (over age 2 years)
    1. Age 2 to 5 years: Give 12.5 to 25 mg orally every 6 to 8 hours (max: 5 mg/kg/day up to 75 mg/day)
    2. Age 6 to 12 years: Give 25 to 50 mg orally every 6 to 8 hours (max: 150 mg/day)

VI. Safety

  1. Pregnancy Category B
  2. Avoid in Lactation

VII. Adverse Effects

  1. See Anticholinergic

VIII. Resources

  1. Dimenhydrinate (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f9302a5a-295a-4501-9332-e3f5eb387362

IX. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 46-7
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Ontology: Dimenhydrinate (C0012381)

Definition (NCI) An ethanolamine and first-generation histamine antagonist with anti-allergic activity. Dimenhydrinate competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, GI smooth muscle spasm.
Definition (MSH) A drug combination that contains DIPHENHYDRAMINE and THEOPHYLLINE. It is used for treating vertigo, motion sickness, and nausea associated with pregnancy. It is not effective in the treatment of nausea associated with cancer chemotherapy.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004111
SnomedCT 387469006, 81073007
LNC LP18075-9, MTHU003001
English Dimenhydrinate, Diphenhydramine Theoclate, Theoclate, Diphenhydramine, 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1), dimenhydrinate (medication), Dimenhydrinate [Chemical/Ingredient], DIMENHYDRINATE, dimenhyDRINATE, dimenhydrinate, Dimenhydrinate (product), Dimenhydrinate (substance), DimenhyDRINATE
Swedish Dimenhydrinat
Czech dimenhydrinát
Finnish Dimenhydrinaatti
Russian DIMENGIDRINAT, DIFENGIDRAMINTEOKLAT, ДИМЕНГИДРИНАТ, ДИФЕНГИДРАМИНТЕОКЛАТ
Italian Difenidramina teoclato, Dimenidrinato
French Diménhydrinate
Polish Dimenhydrynat
Japanese ジメンヒドリナート, ジフェンヒドラミンテオクレート
Portuguese Difenidramina Teoclato, Dimenidrinato, Teoclato de Difenidramina
Spanish dimenhidrinato (producto), dimenhidrinato (sustancia), dimenhidrinato, Difenhidramina Teoclato, Dimenhidrinato
German Dimenhydrinat, Diphenhydramintheoclat
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Dramamine (C0591410)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004111
English McNeil Brand of Dimenhydrinate, Dimenhydrinate McNeil Brand, dramamine, Dramamine
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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