II. Indications
III. Mechanism
- Second Generation Antihistamine
- Loratadine and Desloratadine are less potent than Allegra and Zyrtec
- Deloratadine is the active isomer of Loratadine (and therefore dosed at 50%)
IV. Medications
- Deloratadine (Clarinex) - Prescription only
- Deloratadine is theactive isomer of Loratadine
- Released in 2001, just before the Loratadine patent expired in 2002
- Available by prescription only
- Tablets 5 mg
- Dissolving tablets 2.5 to 5 mg
- Syrup 0.5 mg/ml
- Loratadine (Claritin) - Available OTC
- Tablets 10 mg
- Dissolving tablets 5 to 10 mg
- Syrup 1mg/ml
V. Dosing: Desloratadine (Clarinex)
- FDA approved for perennial allergies in age >=6 months (seasonal allergies in age >=2 years)
- Adult (ages 12 and over): 5 mg orally daily
- Child (ages 6-11 years): 2.5 mg orally daily to twice daily
- Preschool (ages 12 months to 5 years): 1.25 mg orally daily
- Infant (ages 6-12 months): 1 mg orally daily
VI. Dosing: Loratadine (Claritin)
- FDA approved for age >=2 years
- Adult Dose (ages 6 and over): 10 mg orally daily
- Child Dose (ages 2-5 years): 5 mg orally daily
- Decrease dose or spread out doses (every other day) in hepatic insufficiency or Renal Insufficiency
VII. Safety
VIII. Adverse Effects
- See Antihistamine
- Drowsiness
- Although labeled as non-sedating, these Antihistamines may still cause sedation (esp. Cetirizine)
- Sedation may be least likely with Loratadine (Claritin) at lower doses, and Fexofenadine (Allegra) at any dose
- Loratadine may be sedating at higher doses
IX. Resources
X. References
- Howarth (1999) J Allergy Clin Immunol 104:927 [PubMed]
- Walsh (2001) Drugs 61:207 [PubMed]
- (2001) Med Lett Drugs Ther 43(1103):35
Images: Related links to external sites (from Bing)
Related Studies
| loratadine (on 2/22/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| LORATADINE 10 MG ODT | Generic OTC | $0.36 each |
| LORATADINE 10 MG TABLET | Generic OTC | $0.06 each |
| LORATADINE 5 MG/5 ML SOLUTION | Generic OTC | $0.04 per ml |
| LORATADINE 5 MG/5 ML SYRUP | Generic OTC | $0.04 per ml |
| LORATADINE ALLERGY 5 MG/5 ML | Generic OTC | $0.04 per ml |
| LORATADINE-D 12 HOUR TABLET | Generic OTC | $0.76 each |
| LORATADINE-D 24HR TABLET | Generic OTC | $0.57 each |
| desloratadine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DESLORATADINE 5 MG TABLET | Generic | $0.34 each |
| clarinex (on 1/14/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CLARINEX-D 12 HR 2.5-120 MG TB | $5.07 each | |
Ontology: Loratadine (C0065180)
| Definition (NCI) | A piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects. |
| Definition (MSH) | A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D017336 |
| SnomedCT | 108652002, 386884002 |
| LNC | LP21145-5, MTHU012784 |
| English | Loratadine, 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester, 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester, loratadine (medication), 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, Ethyl Ester, loratadine, LORATADINE, Loratadine [Chemical/Ingredient], Loratadine product, Loratadine (product), Loratadine (substance) |
| Swedish | Loratadin |
| Czech | loratadin |
| Finnish | Loratadiini |
| Russian | LORATADIN, ЛОРАТАДИН |
| Japanese | ロラタジン |
| Polish | Loratadyna |
| Spanish | loratadina (producto), loratadina (sustancia), loratadina, Loratadina |
| French | Loratadine |
| German | Loratadin |
| Italian | Loratadina |
| Portuguese | Loratadina |
Ontology: Claritin (C0701055)
| Definition (CHV) | brand name of loratadine |
| Definition (CHV) | brand name of loratadine |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D017336 |
| English | claritin, claritin [brand name], Claritin |
Ontology: desloratadine (C0908935)
| Definition (NCI) | A long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching and spasmodic contractions of gastrointestinal smooth muscle. Desloratadine is used to provide symptomatic relieve of allergic symptoms. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C121345 |
| SnomedCT | 134506008, 396015008 |
| LNC | LP100042-3, MTHU035826 |
| English | 5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-, desloratadine (medication), desloratadine [Chemical/Ingredient], DESLORATADINE, desloratadine, descarboethoxyloratadine, Desloratadine (product), Desloratadine (substance), Desloratadine |
| Spanish | desloratadina (producto), desloratadina (sustancia), desloratadina |
Ontology: Clarinex (C1101146)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C121345 |
| English | Clarinex, clarinex, Essex brand of desloratadine, Neoclarityn, Schering brand of desloratadine, Schering-Plough brand of desloratadine, Aerius |
