II. Indications

III. Mechanism

  1. See Antihistamine
  2. H1 Receptor Antagonist (First Generation Antihistamine)
  3. Meclizine is a synthetic piperazine derivative with Antihistamine (moderate Anticholinergic) and Antiemetic activity

IV. Precautions

  1. Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
    1. Deaths have occurred in younger children related to Anticholinergic Toxicity

V. Dosing

  1. Approved for age >=12 years
  2. Vertigo (not FDA approved)
    1. Dose 25 mg orally four times daily as needed
  3. Motion Sickness
    1. Start: 25 to 50 mg orally 1 hour prior to travel
    2. Next: 25 to 50 mg orally daily during travel

VI. Adverse Effects

VII. Safety

  1. Pregnancy category B
  2. Unknown safety in Lactation

IX. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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Related Studies

Cost: Medications

meclizine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MECLIZINE 12.5 MG CAPLET Generic OTC $0.03 each
MECLIZINE 12.5 MG TABLET Generic $0.08 each
MECLIZINE 25 MG TABLET Generic $0.11 each
MECLIZINE 25 MG TABLET CHEW Generic OTC $0.03 each