II. Indications
III. Mechanism
- See Antihistamine
- H1 Receptor Antagonist (First Generation Antihistamine)
- Meclizine is a synthetic piperazine derivative with Antihistamine (moderate Anticholinergic) and Antiemetic activity
IV. Precautions
- Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
- Deaths have occurred in younger children related to Anticholinergic Toxicity
V. Dosing
- Approved for age >=12 years
-
Vertigo (not FDA approved)
- Dose 25 mg orally four times daily as needed
-
Motion Sickness
- Start: 25 to 50 mg orally 1 hour prior to travel
- Next: 25 to 50 mg orally daily during travel
VI. Adverse Effects
- See Antihistamine
- See Anticholinergic Toxicity
- Sedation
VII. Safety
- Pregnancy category B
- Unknown safety in Lactation
VIII. Resources
IX. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia