II. Indications
III. Mechanism
- See Antihistamine
- H1 Receptor Antagonist
- Chlorpheniramine is an alkylamine First Generation Antihistamine with moderate Anticholinergic activity
IV. Precautions
- Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
- Deaths have occurred in younger children related to Anticholinergic Toxicity
V. Dosing: Regular Release Formulation
- Adult (age >=12 years): 4 mg orally every 4 to 6 hours
- Child (age 6 to 11 years): 2 mg orally every 4 to 6 hours
- Child (age 2 to 5 years): 1 mg orally every 4 to 6 hours (NOT fda approved)
VI. Dosing: Timed Release Formulation
- Adult (age >=12 years): 8 mg orally every 8 hours OR 12 mg orally every 12 hours
- Child (age 6 to 11 years): 8 mg orally every 12 hours (NOT fda approved)
VII. Adverse Effects
- See Antihistamine
- See Anticholinergic Toxicity
- Sedation
VIII. Safety
- Pregnancy category B
- Avoid in Lactation
IX. Resources
- Chlorpheniramine (DailyMed)
X. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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