II. Indications
III. Mechanism
- See Antihistamine
- H1 Receptor Antagonist
- Chlorpheniramine is an alkylamine First Generation Antihistamine with moderate Anticholinergic activity
- Dexchlorpheniramine is the active dextro-isomer of Chlorpheniramine (with twice its potency)
IV. Precautions
- Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
- Deaths have occurred in younger children related to Anticholinergic Toxicity
V. Medications
- Chlorpheniramine (Chlor-Trimeton, Aller-Chlor)
- Regular Release Tablets: 4 mg tablets
- Regular Release Syrup: 2 mg/5 ml
- Extended Release Tablets: 12 mg
- Dexchlorpheniramine (Polaramine, Polmon)
- Oral Solution: 2 mg/5 ml
VI. Dosing: Chlorpheniramine Regular Release Formulation
- Adult (age >=12 years): 4 mg orally every 4 to 6 hours
- Child (age 6 to 11 years): 2 mg orally every 4 to 6 hours
- Child (age 2 to 5 years): 1 mg orally every 4 to 6 hours (NOT fda approved)
VII. Dosing: Chlorpheniramine Timed Release Formulation
- Adult (age >=12 years): 8 mg orally every 8 hours OR 12 mg orally every 12 hours
- Child (age 6 to 11 years): 8 mg orally every 12 hours (NOT fda approved)
VIII. Dosing: Dexchlorpheniramine
- Adult (and child age>=12 years): 2 mg (or 1 tsp solution) every 4 to 6 hours as needed
- Child age 6 to 11 years: 1 mg (or 1/2 tsp solution) every 4 to 6 hours as needed
- Child age 2 to 5 years: 0.5 mg (or 1/4 tsp solution) every 4 to 6 hours as needed
IX. Adverse Effects
- See Antihistamine
- See Anticholinergic Toxicity
- Sedation
X. Safety
- Pregnancy category B
- Avoid in Lactation
XI. Resources
- Chlorpheniramine (DailyMed)
- Dexchlorpheniramine (DailyMed)
XII. References
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| aller-chlor (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ALLER-CHLOR 4 MG TABLET | Generic OTC | $0.02 each |
Ontology: Chlorpheniramine (C0008281)
| Definition (MSH) | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. |
| Definition (CSP) | histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, asthma and in veterinary applications; one of the most widely used of the classical antihistamines. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D002744 |
| SnomedCT | 9944001, 372914003 |
| LNC | LP16072-8, MTHU006724 |
| English | Chlorphenamine, Chlorpheniramine, Chlorprophenpyridamine, 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, Chlorpheniramine (Allergy), chlorpheniramines (medication), chlorpheniramine (medication), chlorpheniramines, antihistamines chlorpheniramines, Chlorpheniramine [Chemical/Ingredient], CHLORPHENIRAMINE, 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine, Chlorophenylpyridamine, 4-Chloropheniramine, Chloropheniramine, chlorpheniramine, chlorphenamine, Chlorpheniramine (product), Chlorpheniramine (substance) |
| Swedish | Klorfeniramin |
| Czech | chlorfeniramin |
| Finnish | Kloorifeniramiini |
| Russian | KHLORFENAMIN, KHLORFENIRAMIN, KHLORPROFENPIRIDAMIN, ХЛОРПРОФЕНПИРИДАМИН, ХЛОРФЕНАМИН, ХЛОРФЕНИРАМИН |
| Japanese | クロルプロフェンピリダミン, マレイン酸クロルフェニラミン, クロルフェニラミン, クロルフェナミン |
| Italian | Clorprofenpiridamina, Clorofenamina, Clorofeniramina |
| Spanish | Clorfeniramina, Clorprofenpiridamina, Clorofeniramina, Cloroprofenpiridamina, clorfeniramina (producto), clorfeniramina (sustancia), clorfeniramina, Clorfenamina |
| Polish | Chlorfeniramina, Chlorfenamina |
| French | Chlorphénamine, Chlorphéniramine |
| German | Chlorphenamin, Chlorpheniramin, Chlorprophenpyridamin |
| Portuguese | Clorfenamina, Clorfeniramina, Clorprofempiridamina |
