II. Epidemiology
- Emerging cause of Chronic Cough in pulmonology clinics
- Responsible for 10-30% of Chronic Cough cases referred to pulmonology
III. Differential Diagnosis
IV. Diagnosis
- Normal airway hyper-responsiveness (i.e. not Asthma)
- Normal Spirometry
- Normal airway responsiveness on Methacholine inhalation test
- Sputum Eosinophilia (i.e. not Chronic Bronchitis)
- Induced Sputum (via saline nebulization) with 3% or more Eosinophils
- No signs variable airflow obstruction
V. Management
- Does not respond to Inhaled Bronchodilators
- Eliminate Occupational Lung Disease and inhaled allergan exposures
- High-dose Inhaled Corticosteroids
- Brief initial course of Systemic Corticosteroids may be considered if Inhaled Corticosteroids ineffective